Cebra C K, Garry F B, Powers B E, Johnson L W
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
J Vet Intern Med. 1995 Nov-Dec;9(6):381-5. doi: 10.1111/j.1939-1676.1995.tb03297.x.
We evaluated the medical information from 10 New World Camelids with lymphosarcoma. Additionally, tumor tissue from 5 animals was examined by electron microscopy for evidence of retroviral particles. Lymphosarcoma was the most common neoplasm of New World Camelids in our hospital. Both llamas and alpacas, from 4 months to 15 years of age, were affected. Emaciation (7 of 8) and palpable masses (9 of 10) were the most common physical examination abnormalities, and a left-shifted leukogram (7 of 7) and hypoalbuminemia (6 of 7) were the most characteristic clinicopathologic findings. Lymphosarcoma was diagnosed by lymph node aspirate (n = 2), biopsy (n = 2), peritoneal fluid analysis (n = 2), or necropsy (n = 4). The clinical course after recognition of the disease was usually short, with a median survival of 1 month (1 week to 3 months). Organs with neoplastic infiltrates commonly included lymph nodes (n = 8), liver (n = 8), kidneys (n = 6), and lungs (n = 5). No retroviral particles were detected ultrastructurally.
我们评估了10只患有淋巴肉瘤的新大陆骆驼科动物的医学信息。此外，对5只动物的肿瘤组织进行了电子显微镜检查，以寻找逆转录病毒颗粒的证据。在我们医院，淋巴肉瘤是新大陆骆驼科动物最常见的肿瘤。患病动物包括4个月至15岁的美洲驼和羊驼。消瘦（8只中的7只）和可触及肿块（10只中的9只）是最常见的体格检查异常，白细胞计数左移（7只中的7只）和低白蛋白血症（7只中的6只）是最具特征性的临床病理表现。淋巴肉瘤通过淋巴结穿刺（n = 2）、活检（n = 2）、腹腔液分析（n = 2）或尸检（n = 4）确诊。确诊疾病后的临床病程通常较短，中位生存期为1个月（1周-3个月）。出现肿瘤浸润的器官通常包括淋巴结（n = 8）、肝脏（n = 8）、肾脏（n = 6）和肺（n = 5）。超微结构检查未检测到逆转录病毒颗粒。
