Tachibana K, Kazatani Y, Kodama K, Matsuzaki K, Murakami E, Kokubu T
Department of Internal Medicine, Kinki Central Hospital, Itami, Japan.
Jpn Heart J. 1995 Sep;36(5):669-73. doi: 10.1536/ihj.36.669.
Vasospastic angina was observed in two sisters. The 52-year-old younger sister presented with rest angina at midnight and in the early morning. The coronary arteriogram showed no significant organic stenosis. Vasospasm to the left anterior descending and right coronary arteries was induced by the intracoronary administration of acetylcholine. The 57-year-old elder sister complained of rest and effort angina. Her coronary arteriogram was also normal. Vasospasm to the left circumflex and right coronary arteries was provoked by acetylcholine. In both cases, human leukocyte antigen DQw3 was negative. In the present cases, genetic factors may partly contribute to the mechanism of vasospastic angina.
在两姐妹中观察到血管痉挛性心绞痛。52岁的妹妹表现为午夜和清晨时的静息性心绞痛。冠状动脉造影显示无明显器质性狭窄。冠状动脉内注射乙酰胆碱可诱发左前降支和右冠状动脉痉挛。57岁的姐姐主诉有静息性和劳力性心绞痛。她的冠状动脉造影也正常。左旋支和右冠状动脉对乙酰胆碱激发试验呈阳性反应。在这两个病例中，人类白细胞抗原DQw3均为阴性。在本病例中，遗传因素可能在一定程度上促成了血管痉挛性心绞痛的发病机制。
