Kanegae K, Itoh K, Tsukamoto E, Kato C, Nakada K, Mochizuki T, Shiga T, Furudate M
Department of Nuclear Medicine, Hokkaido University, School of Medicine.
Kaku Igaku. 1995 Nov;32(11):1263-8.
We performed radionuclide scanning after intravenous administration of 80 MBq of 111In-labeled non-specific polyclonal human immunoglobulin G (111In-DTPA-IgG). Serial scintigrams were acquired at 6, 24, 48, and 72 hr after injection in 10 patients suspected of having inflammation and/or infection. In 5 patients, the results of scintigraphy were verified with intraoperative cultures or biopsy. The values were as follow: sensitivity: 100% (4/4); specificity 50% (3/6); accuracy: 70% (7/10); positive predictive value: 57.1% (4/7); and negative predictive value: 100% (3/3). The results indicate that 111In-DTPA-IgG scintigraphy is certainly a promising method for the detection of inflammation and/or infection.
我们在静脉注射80MBq的111In标记的非特异性多克隆人免疫球蛋白G（111In-DTPA-IgG）后进行了放射性核素扫描。对10名疑似患有炎症和/或感染的患者在注射后6、24、48和72小时获取了系列闪烁扫描图像。在5名患者中，闪烁扫描结果通过术中培养或活检得到了验证。结果如下：敏感性：100%（4/4）；特异性：50%（3/6）；准确性：70%（7/10）；阳性预测值：57.1%（4/7）；阴性预测值：100%（3/3）。结果表明，111In-DTPA-IgG闪烁扫描无疑是一种用于检测炎症和/或感染的有前景的方法。
