Serafini A N, Garty I, Vargas-Cuba R, Friedman A, Rauh D A, Neptune M, Landress L, Sfakianakis G N
University of Miami/Jackson Memorial Medical Center, Florida.
J Nucl Med. 1991 Dec;32(12):2227-32.
This study was undertaken as part of a Phase II study to assess the sensitivity and safety of 111In-DTPA-human IgG, an imaging agent for the detection of inflammations and/or infections. Forty patients with infection/inflammation on the basis of clinical findings, microbiologic results, and/or the basis of results from other imaging modalities were studied. For evaluation of sensitivity, whole-body images were obtained at 6-12 hr (early) and 20-28 hr (delayed) postinjection and occasionally at 48 hr. No adverse reactions were recorded in any of the 40 patients studied. Positive results were obtained in 37 of 37 evaluable subjects (100%). The test appears to be a promising method for the detection of inflammation and/or infection.
本研究作为一项II期研究的一部分开展，旨在评估铟-111标记的二乙三胺五乙酸人免疫球蛋白（111In-DTPA-human IgG）作为一种用于检测炎症和/或感染的显像剂的敏感性和安全性。基于临床发现、微生物学结果和/或其他成像检查结果，对40例存在感染/炎症的患者进行了研究。为评估敏感性，在注射后6-12小时（早期）和20-28小时（延迟期）进行全身显像，偶尔在48小时进行显像。在所研究的40例患者中均未记录到不良反应。在37例可评估受试者中有37例（100%）获得阳性结果。该检测方法似乎是一种很有前景的炎症和/或感染检测方法。
