Salmerón F J, Gila A, Oyonarte S, Palacios A, Pérez Ruiz M, Fernández Montoya A, Ruiz Extremera A
Servicio de Digestivo Hospital Universitario, Centro Regional de Transfusión Sanguínea, Granada.
Med Clin (Barc). 1995 Nov 18;105(17):641-4.
The incidence of post transfusional hepatitis (PTH) after the exclusion of anti-HCV ELISA 2 positive donors is not well known. The aim of this study was to determine the incidence and type of PTH in 113 post transfused patients.
A post transfusional follow up was performed for at least one year with periodic controls of transaminase levels. When an increase in GPT level compatible with PTH was demonstrated investigation of all the virus related with the transfusion was carried out in both the donor and the transfused subject: HAV, HCV, HEV, HBV and CMV.
Four cases (3.5%) were detected which fulfilled the PTH criteria with the following characteristics: short period of time between transfusion and the increase in GPT level, moderate GPT increase, moderate clinical expression and good evolution. In all the cases the viral study was negative and other non viral possibilities were eliminated.
Transfusions are currently relatively safe and the increase in transaminases may not be related with transfusion.
排除抗丙型肝炎病毒酶联免疫吸附试验2阳性献血者后，输血后肝炎（PTH）的发病率尚不清楚。本研究的目的是确定113例输血后患者中PTH的发病率和类型。
对输血后患者进行至少一年的随访，并定期检测转氨酶水平。当谷丙转氨酶（GPT）水平升高符合PTH时，对献血者和受血者进行与输血相关的所有病毒检测：甲型肝炎病毒（HAV）、丙型肝炎病毒（HCV）、戊型肝炎病毒（HEV）、乙型肝炎病毒（HBV）和巨细胞病毒（CMV）。
检测到4例（3.5%）符合PTH标准的病例，具有以下特点：输血与GPT水平升高之间的时间间隔短、GPT中度升高、临床表现中度且病情进展良好。所有病例的病毒检测均为阴性，其他非病毒因素也被排除。
目前输血相对安全，转氨酶升高可能与输血无关。
