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[刚果的血吸虫病与人类免疫缺陷病毒感染]

[Bilharziasis and human immunodeficiency virus infection in Congo].

作者信息

N'Zoukoudi-N'Doundou M Y, Dirat I, Akouala J J, Penchenier L, Makuwa M, Rey J L

机构信息

Laboratoire d'Epidémiologie des Grandes Endémies Tropicales, Brazzaville, Congo.

出版信息

Med Trop (Mars). 1995;55(3):249-51.

PMID:8559022
Abstract

To assess the relationship between schistosomiasis and human immunodeficiency virus (HIV) infection, a cross-sectional study of HIV seroprevalence was carried out in 1992 in a village in the Bouenza region of the Congo where there is a high incidence of urinary schistosomiasis. No correlation was found between eggs in urine and positive serology for HIV in the 895 adults examined nor between positive schistosome serology and positive HIV serology. The incidence of frank schistosome infection (eggs in urine and positive blood tests) was significantly lower in patients with positive HIV serology (3.5%) than in patients with negative HIV serology (6.7%). Similarly the mean number of eggs in urine was significantly lower in patients with positive HIV serology (3.6 eggs per ml) than in patients with negative HIV serology (26.6 eggs per ml) (p < 0.01). These observations suggest that HIV infection limits schistosome development and decreases antibody production. Further study will be needed to confirm these findings.

摘要

为评估血吸虫病与人类免疫缺陷病毒(HIV)感染之间的关系,1992年在刚果布恩泽地区一个村庄开展了一项关于HIV血清流行率的横断面研究,该地区尿路血吸虫病发病率很高。在所检查的895名成年人中,尿中虫卵与HIV血清学阳性之间以及血吸虫血清学阳性与HIV血清学阳性之间均未发现相关性。HIV血清学阳性患者中明显的血吸虫感染(尿中虫卵及血检阳性)发生率(3.5%)显著低于HIV血清学阴性患者(6.7%)。同样,HIV血清学阳性患者尿中虫卵的平均数量(每毫升3.6个虫卵)显著低于HIV血清学阴性患者(每毫升26.6个虫卵)(p<0.01)。这些观察结果表明,HIV感染会限制血吸虫的发育并减少抗体产生。需要进一步研究来证实这些发现。

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