Fishback A S, Shields C B, Linden R D, Zhang Y P, Burke D
Department of Neurological Surgery, University of Louisville, Kentucky, USA.
Neurosurgery. 1995 Nov;37(5):969-74. doi: 10.1227/00006123-199511000-00017.
INTRAOPERATIVE MONITORING OF motor evoked potentials (MEPs) may become a valuable test of spinal cord function during surgery. Unfortunately, MEP responses are affected by most common anesthetics. We studied the effect of intravenous propofol on transcranial magnetic MEPs (tcMMEPs) in the rat. Baseline tcMMEPs were recorded before administration of the drug. Each rat then received three induction doses of propofol, 10, 5, and 5 mg/kg (totaling 10, 15, and 20 mg/kg) and three successive 20-minute infusion doses at rates of 10, 20, and 40 mg/kg/h, respectively. An MEP intensity series was performed after each induction dose, during each infusion, and during a 20-minute recovery period. tcMMEPs recorded during the induction period demonstrated a significant, dose-dependent increase in onset latency and a marked decrease in amplitude. Infusion tcMMEPs displayed increased onset latencies but demonstrated a significant change in amplitudes only after the largest infusion dose. The MEPs approached baseline levels after discontinuation of the propofol. This study demonstrates that tcMMEPs can be successfully recorded from the rat during propofol anesthesia.
术中监测运动诱发电位（MEP）可能会成为手术期间脊髓功能的一项有价值的检测方法。不幸的是，MEP反应会受到大多数常用麻醉剂的影响。我们研究了静脉注射丙泊酚对大鼠经颅磁运动诱发电位（tcMMEP）的影响。在给药前记录基线tcMMEP。然后，每只大鼠接受三次诱导剂量的丙泊酚，分别为10、5和5mg/kg（总计10、15和20mg/kg），以及三次连续20分钟的输注剂量，速率分别为10、20和40mg/kg/h。在每次诱导剂量后、每次输注期间以及20分钟的恢复期内进行MEP强度系列检测。在诱导期记录的tcMMEP显示起始潜伏期有显著的剂量依赖性增加，波幅明显降低。输注tcMMEP显示起始潜伏期增加，但仅在最大输注剂量后波幅才有显著变化。丙泊酚停药后，MEP接近基线水平。本研究表明，在丙泊酚麻醉期间可以成功地从大鼠记录到tcMMEP。
