Valldeoriola F, Graus F, Rimola A, Andreu H, Santamaria J, Catafau A, Visa J, Tolosa E, Rodés J
Service of Neurology, Hospital Clínic i Provincial, Barcelona, Spain.
Neurology. 1996 Jan;46(1):252-4. doi: 10.1212/wnl.46.1.252.
Four liver transplant recipients treated with cyclosporine developed a reversible neurologic syndrome characterized by a speech disorder leading to mutism. This complication, previously reported in a few liver transplant recipients treated with the immunosuppressive drug FK506, had not been described with cyclosporine. Recognition of this syndrome should prompt withdrawal of the drug and avoidance of unnecessary diagnostic procedures.
四名接受环孢素治疗的肝移植受者出现了一种可逆性神经综合征，其特征为言语障碍导致缄默症。这种并发症此前在少数接受免疫抑制药物FK506治疗的肝移植受者中已有报道，但环孢素治疗的患者中尚未见描述。认识到这种综合征应促使停用该药物并避免不必要的诊断程序。
