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电休克治疗对一例非紧张型偏执型精神分裂症所致长期缄默症的疗效

Electroconvulsive Therapy for Long-term Mutism in a Case of Noncatatonic Paranoid Schizophrenia.

作者信息

Basu Aniruddha, Singh Priti, Gupta Rajiv, Kundu Savita

机构信息

Dr. Basu is Senior Resident, Department of Psychiatry, Pt.B.D. Sharma PGIMS, Rohtak, Haryana, India; Dr. Singh is Professor, Department of Psychiatry, Pt.B.D. Sharma PGIMS Rohtak, Haryana, India; Dr. Gupta is Senior Professor and Head, Department of Psychiatry, Pt.B.D.Sharma Rohtak, Haryana, India; and Dr. Kundu is Junior Resident, Department of Psychiatry, Pt.B.D.Sharma PGIMS Rohtak, Haryana, India.

出版信息

Innov Clin Neurosci. 2013 Jul;10(7-8):10-2.

PMID:24062967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3779904/
Abstract

We report a rare case of paranoid schizophrenia presenting with continuous mutism for about three years. This 26-year-old woman with multiple Schneiderian first-rank symptoms ['Schneiderian' refers to those symptoms established by the German psychiatrist Kurt Schneider for the diagnosis of schizophrenia] did not have any catatonic features, and she would fluently communicate by gesturing or writing. Since there was serious impairment in biological functions not readily correctable by antipsychotics, she was started on electroconvulsive therapy. She responded well to 14 sessions of electroconvulsive therapy along with oral haloperidol. We also discuss the cultural implications of prolonged mutism. To the best of our knowledge, this is the first case of mutism in noncatatonic paranoid schizophrenia that responded well to electroconvulsive therapy described in the literature.

摘要

我们报告一例罕见的偏执型精神分裂症病例,患者持续缄默约三年。这位26岁的女性具有多种施奈德一级症状(“施奈德”指德国精神病学家库尔特·施奈德确立的用于精神分裂症诊断的那些症状),没有任何紧张症特征,她会通过手势或书写流畅地交流。由于存在生物功能严重受损且抗精神病药物难以纠正的情况,她开始接受电休克治疗。她对14次电休克治疗以及口服氟哌啶醇反应良好。我们还讨论了长期缄默的文化影响。据我们所知,这是文献中描述的首例非紧张症性偏执型精神分裂症缄默且对电休克治疗反应良好的病例。

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引用本文的文献

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Switching to aripiprazole for the treatment of residual mutism resulted in distinct clinical courses in two catatonic schizophrenia cases.在两例紧张型精神分裂症病例中,换用阿立哌唑治疗残留性缄默症导致了不同的临床病程。
SAGE Open Med Case Rep. 2017 Feb 8;5:2050313X17692936. doi: 10.1177/2050313X17692936. eCollection 2017.
2
Rapid Response of Long-Standing, Treatment-Resistant Non-Catatonic Mutism in Paranoid Schizophrenia with Single ECT session.单次电休克治疗对偏执型精神分裂症长期存在的、治疗抵抗性非紧张性缄默症的快速反应
N Am J Med Sci. 2014 Nov;6(11):591-4. doi: 10.4103/1947-2714.145480.

本文引用的文献

1
17 years of treatment-resistant mutism in non-catatonic, childhood-onset schizophrenia: a rare case report.17年难治性缄默症在非紧张型、儿童期起病的精神分裂症中的病例报告:一例罕见病例
J Neuropsychiatry Clin Neurosci. 2012 Winter;24(1):E39-40. doi: 10.1176/appi.neuropsych.11020045.
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Clozapine-resistant mutism in noncatatonic schizophrenia.非紧张型精神分裂症中对氯氮平耐药的缄默症
J Postgrad Med. 2007 Jan-Mar;53(1):75-6. doi: 10.4103/0022-3859.30337.
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Mutism: review, differential diagnosis, and report of 22 cases.缄默症:综述、鉴别诊断及22例报告
Am J Psychiatry. 1986 Nov;143(11):1409-14. doi: 10.1176/ajp.143.11.1409.