Yamamoto S, Kawahara K, Takahashi T, Tagawa T, Nakamura A, Muraoka M, Tomita M
First Department of Surgery, Nagasaki University School of Medicine, Japan.
Respiration. 1995;62(5):244-7. doi: 10.1159/000196456.
We attempted to develop a pulmonary hypertension model in dogs by gelatin sponge embolization. We then monitored right-ventricular pressure overload by echocardiography. Gelatin sponges (Spongel, Yamanouchi, Tokyo) were homogenized and mixed in normal saline (0.6 mg/ml). The mixture was administered via the jugular vein to general pulmonary emboli. Repeated administration of the sponges increased the mean pulmonary arterial pressure and caused right ventricular pressure overload. The degree of pulmonary hypertension was proportional to the volume of gelatin sponge injected. Echocardiography, performed both before and after embolization, proved useful assessing for the degree of right-ventricular pressure overload.
我们试图通过明胶海绵栓塞建立犬肺动脉高压模型。然后，我们通过超声心动图监测右心室压力负荷。将明胶海绵（Spongel，山之内制药，东京）匀浆并混入生理盐水（0.6mg/ml）中。将该混合物经颈静脉注入形成全肺栓塞。重复注入海绵可使平均肺动脉压升高，并导致右心室压力负荷增加。肺动脉高压的程度与注入的明胶海绵体积成正比。栓塞前后进行的超声心动图检查被证明有助于评估右心室压力负荷的程度。
