Gutiérrez J, Rodríguez M, Maroto M C
Departamento de Microbiología, Hospital Universitario San Cecilio, Universidad de Granada, España.
Rev Med Chil. 1995 Jul;123(7):819-22.
The aim of this work was to relate the avidity of specific IgG antibodies with the time of evolution of human brucella infection. IgG anti-brucella antibodies were measured using an ELISA assay with 8 M urea in 17 patients with recent active brucellosis (group I), 31 patients with chronic active brucellosis (group II) and 120 asymptomatic patients with past brucellosis (group III). Twelve patients of group I (70.6%), three of group II (9.7%) and none in group III had low avidity antibodies against Brucella. It is concluded that these antibodies have a high diagnostic efficiency for recent Brucella infections.
这项工作的目的是将特异性IgG抗体的亲和力与人类布鲁氏菌感染的病程时间联系起来。使用含8M尿素的ELISA检测法，对17例近期患有活动性布鲁氏菌病的患者（第一组）、31例慢性活动性布鲁氏菌病患者（第二组）和120例既往患过布鲁氏菌病的无症状患者（第三组）进行了IgG抗布鲁氏菌抗体检测。第一组的12例患者（70.6%）、第二组的3例患者（9.7%）以及第三组的患者均未检测到低亲和力抗布鲁氏菌抗体。得出的结论是，这些抗体对近期布鲁氏菌感染具有较高的诊断效率。
