Weber G F, Ashkar S, Glimcher M J, Cantor H
Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Science. 1996 Jan 26;271(5248):509-12. doi: 10.1126/science.271.5248.509.
The CD44 family of surface receptors regulates adhesion, movement, and activation of normal and neoplastic cells. The cytokine osteopontin (Eta-1), which regulates similar cellular functions, was found to be a protein ligand of CD44. Osteopontin induces cellular chemotaxis but not homotypic aggregation, whereas the inverse is true for the interaction between CD44 and a carbohydrate ligand, hyaluronate. The different responses of cells after CD44 ligation by either osteopontin or hyaluronate may account for the independent effects of CD44 on cell migration and growth. This mechanism may also be exploited by tumor cells to promote metastasis formation.
CD44表面受体家族调节正常细胞和肿瘤细胞的黏附、运动及激活。细胞因子骨桥蛋白（Eta-1）也调节类似的细胞功能，它被发现是CD44的一种蛋白质配体。骨桥蛋白可诱导细胞趋化性，但不诱导同型聚集，而CD44与碳水化合物配体透明质酸之间的相互作用则相反。骨桥蛋白或透明质酸与CD44结合后细胞产生的不同反应，可能解释了CD44对细胞迁移和生长的独立作用。肿瘤细胞也可能利用这一机制促进转移灶的形成。
