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地中海贫血患者血管内皮细胞相关血浆蛋白的改变及其与临床症状的相关性。

Alterations in vascular endothelial cell-related plasma proteins in thalassaemic patients and their correlation with clinical symptoms.

作者信息

Butthep P, Bunyaratvej A, Funahara Y, Kitaguchi H, Fucharoen S, Sato S, Bhamarapravati N

机构信息

Blood Disease Research Unit, Sirikit Medical Centre, Bangkok, Thailand.

出版信息

Thromb Haemost. 1995 Oct;74(4):1045-9.

PMID:8560411
Abstract

An increased level of plasma thrombomodulin (TM) in alpha- and beta-thalassaemia was demonstrated using an enzyme-linked immunosorbent assay (ELISA). Nonsplenectomized patients with beta-thalassaemia/haemoglobin E (BE) had higher levels of TM than splenectomized cases (BE-S). Patients with leg ulcers (BE-LU) were found to have the highest increase in TM level. Appearance of larger platelets in all types of thalassaemic blood was observed indicating an increase in the number of younger platelets. These data indicate that injury of vascular endothelial cells is present in thalassaemic patients.

摘要

采用酶联免疫吸附测定（ELISA）法证实，α-地中海贫血和β-地中海贫血患者血浆血栓调节蛋白（TM）水平升高。非脾切除的β-地中海贫血/血红蛋白E（BE）患者的TM水平高于脾切除病例（BE-S）。发现腿部溃疡患者（BE-LU）的TM水平升高幅度最大。观察到所有类型的地中海贫血血液中出现更大的血小板，表明年轻血小板数量增加。这些数据表明，地中海贫血患者存在血管内皮细胞损伤。

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