Atouguia J M, Jennings F W, Murray M
Centro de Malaria e Doenças Tropicais, Lisbon, Portugal.
Trans R Soc Trop Med Hyg. 1995 Sep-Oct;89(5):531-3. doi: 10.1016/0035-9203(95)90098-5.
Melarsoprol gel applied topically (0.1 mL for at least 2 d) can cure late-stage Trypanosoma brucei brucei and T. b. rhodesiense infections in mice. The best regimen was 3 applications at approximately 0, 6, and 24 h. The melarsoprol gel retained its activity at room temperature for at least 63 d. There was only minimal skin irritation and no sign of toxicity.
局部应用美拉胂醇凝胶（0.1 mL，至少2天）可治愈小鼠晚期布氏布氏锥虫和罗德西亚锥虫感染。最佳给药方案是在大约0、6和24小时各给药一次，共3次。美拉胂醇凝胶在室温下至少63天保持活性。只有轻微的皮肤刺激，没有毒性迹象。
