Hagel I, Lynch N R, Di Prisco M C, Sanchez J, Pérez M
Instituto de Biomedicina, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.
Trans R Soc Trop Med Hyg. 1995 Sep-Oct;89(5):562-5. doi: 10.1016/0035-9203(95)90109-4.
Helminthic infection can stimulate the interleukin-4 (IL-4)-dependent polyclonal synthesis of immunoglobulin E (IgE) in children endemically exposed to these parasites. As such children are also frequently at nutritional risk, in this study we considered the possible influence of malnutrition on serum IL-4 levels and the IgE response in helminthic infection. We evaluated 85 Ascaris-infected children living in an urban slum area of Caracas, Venezuela, and found that the serum levels of IL-4 and total IgE were significantly higher in malnourished children than in their well nourished counterparts. In contrast, the specific anti-Ascaris IgE antibody response was significantly lower in the malnourished group. After anthelmintic treatment of the children, the total serum IgE and IL-4 levels decreased significantly in the well nourished group, while the specific anti-Ascaris IgE antibody response increased. No significant change was detected, however, in the malnourished group. Our results suggested that malnutrition potentiates the polyclonal stimulation of IgE synthesis induced by helminths. As specific IgE antibody has been implicated in the resistance to helminthic infection, and the polyclonal stimulus diminishes this response, these factors may increase the susceptibility of malnourished children to such parasites.
蠕虫感染可刺激那些在地方病流行区经常接触这些寄生虫的儿童体内依赖白细胞介素-4（IL-4）的免疫球蛋白E（IgE）多克隆合成。由于这些儿童也常常面临营养风险，在本研究中，我们考虑了营养不良对蠕虫感染时血清IL-4水平及IgE反应的可能影响。我们评估了委内瑞拉加拉加斯一个城市贫民区的85名感染蛔虫的儿童，发现营养不良儿童的血清IL-4和总IgE水平显著高于营养良好的儿童。相比之下，营养不良组的特异性抗蛔虫IgE抗体反应显著较低。对这些儿童进行驱虫治疗后，营养良好组的血清总IgE和IL-4水平显著下降，而特异性抗蛔虫IgE抗体反应增加。然而，营养不良组未检测到显著变化。我们的结果表明，营养不良增强了蠕虫诱导的IgE合成的多克隆刺激。由于特异性IgE抗体与抗蠕虫感染有关，而多克隆刺激会减弱这种反应，这些因素可能会增加营养不良儿童对这类寄生虫的易感性。
