Hagel I, Lynch N R, Di Prisco M C, Rojas E, Pérez M, Alvarez N
Institute of Biomedicine, Faculty of Medicine, Central University of Venezuela, Caracas.
Clin Exp Immunol. 1993 Oct;94(1):80-3. doi: 10.1111/j.1365-2249.1993.tb05981.x.
Total and Ascaris-specific serum IgE levels were measured in a group of 98 Ascaris-infected children from a slum area of Caracas, Venezuela, in whom the infections were eliminated by regular treatment for 22 months with the anthelmint Oxantel/Pyrantel ('Quantrel'). The children were re-evaluated at the end of the treatment programme, and then 8 months later, at which time reinfection was assessed. Total IgE levels at the beginning of the study were significantly higher in the children who became reinfected after treatment, compared with those who did not. The anthelmint treatment caused a significant decrease in the total IgE levels in most of the children, and after a period of 8 months without treatment these continued to decrease in the non-reinfected group, but increased again in the reinfected children. The reverse pattern was found for Ascaris-specific IgE antibody levels, and in fact an inverse correlation was found between total and anti-Ascaris IgE levels. Striking associations were found between reinfection and high pretreatment values of total IgE, but low levels of specific IgE antibody. These data support the concept that specific IgE antibody may participate in the protection against helminthic infection, and suggest that the polyclonal stimulation of IgE synthesis caused by these parasites may reduce the effectiveness of such responses. The results also indicate that different individuals have varying propensities to respond polyclonally to the helminths, and this influences their resistance to infection.
在委内瑞拉加拉加斯一个贫民窟地区，对98名感染蛔虫的儿童进行了血清总IgE水平和蛔虫特异性IgE水平的检测。这些儿童接受了22个月的驱虫药奥克太尔/噻嘧啶（“Quantrel”）常规治疗，感染得以消除。在治疗方案结束时对这些儿童进行了重新评估，然后在8个月后再次评估，此时评估再感染情况。研究开始时，治疗后发生再感染的儿童的总IgE水平显著高于未发生再感染的儿童。驱虫治疗使大多数儿童的总IgE水平显著下降，在未经治疗的8个月期间，未再感染组的总IgE水平持续下降，但再感染儿童的总IgE水平再次升高。蛔虫特异性IgE抗体水平呈现相反的模式，事实上，总IgE水平与抗蛔虫IgE水平之间存在负相关。在再感染与治疗前总IgE高值但特异性IgE抗体水平低值之间发现了显著关联。这些数据支持特异性IgE抗体可能参与抵抗蠕虫感染的概念，并表明这些寄生虫引起的IgE合成多克隆刺激可能会降低此类反应的有效性。结果还表明，不同个体对蠕虫多克隆反应的倾向不同，这影响了他们对感染的抵抗力。
