Yilmaz G G, Güven A G
Department of Pediatrics, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Turk J Pediatr. 1995 Oct-Dec;37(4):411-4.
The efficacy of cyclosporin-A, a potent immunosuppressive agent, has not been clearly proven in the management of childhood nephrotic syndrome. The occurrence of early relapse as the dose of cyclosporin is tapered or as soon as the drug is stopped and the potential nephrotoxic effects of prolonged treatment have caused it to be used in limited cases. We report an eighteen-month-old boy with steroid toxicity and alkylating agents-resistant nephrotic syndrome, who subsequently went very quickly into remission lasting at least one year after receiving cyclosporin-A for only three months.
强效免疫抑制剂环孢素A在儿童肾病综合征治疗中的疗效尚未得到明确证实。随着环孢素剂量逐渐减少或一旦停药，早期复发情况就会出现，而且长期治疗可能产生的肾毒性作用导致其仅在有限的病例中使用。我们报告了一名18个月大的患有类固醇毒性和对烷化剂耐药的肾病综合征男孩，他在仅接受三个月的环孢素A治疗后，很快就进入了持续至少一年的缓解期。
