Salimov R M, Poletaeva I I, Kovalev G I, Salimova N B, Gaĭnetdinov R R
Zh Vyssh Nerv Deiat Im I P Pavlova. 1995 Sep-Oct;45(5):914-24.
C57BL/6J (B6) and CBA mice with normal karyotype and respective substrains carrying robertsonian translocation (fusion) of chromosomes 8 and 17 (Rb) were compared in their ability to extrapolate the direction of stimulus movement disappearing from the field of vision, rearings and hole-poke responses, and exploration strategies in a plus-maze. Rb mice were shown to be superior to normal karyotype groups in extrapolation behaviour. The pattern of interstrain differences in noradrenaline level in the cortex and serotonin turnover indices in the hippocampus correlated with differences in extrapolation ability, while exploration strategies in the plus-maze correlated with differences in dopamine level and its turnover rate in the neocortex and striatum. The data demonstrated that chromosomal rearrangement inducing behavioural differences was accompanied also by discrete neurochemical changes, and that spatial exploration strategies (being probably the constituent of general spatial abilities of mice) were to a large extent independent from extrapolation ability which was regarded as the index of animal reasoning capacity.
将具有正常核型的C57BL/6J（B6）和CBA小鼠以及分别携带8号和17号染色体罗伯逊易位（融合）（Rb）的亚系小鼠，在推断从视野中消失的刺激运动方向的能力、竖毛和洞戳反应以及在十字迷宫中的探索策略方面进行了比较。结果显示，Rb小鼠在外推行为方面优于正常核型组。皮质中去甲肾上腺素水平和海马中5-羟色胺周转率指标的品系间差异模式与外推能力的差异相关，而十字迷宫中的探索策略与新皮质和纹状体中多巴胺水平及其周转率的差异相关。数据表明，诱导行为差异的染色体重排也伴随着离散的神经化学变化，并且空间探索策略（可能是小鼠一般空间能力的组成部分）在很大程度上独立于被视为动物推理能力指标的外推能力。
