van den Steen P, van Lommel A, Lauweryns J M
Laboratorium voor Histopathologie, Faculteit Geneeskunde, Katholieke Universiteit te Leuven, Belgium.
Acta Anat (Basel). 1995;153(2):85-95. doi: 10.1159/000147718.
In studying epithelio-stromal interactions in the neonatal hamster lung, basal centrioles, basal cilia and open-ring centrioles attracted our attention. The same structures are also found in bronchiolar epithelium of a 3-week-old fawn-hooded rat, indicating that they are not specific phenomena of hamster lung. Although cells with basal centrioles are not common, they are more readily observed in a sample of bronchioles at the second postnatal week as compared to the fourth neonatal day. The centrioles may often possess two satellites and function as microtubule organizing centers (MTOC). Open-ring centrioles are mature structures and also serve as MTOC. Apparently, triplets may de novo be added to and/or degraded from an open-ring centriole. The basal cilia and the cilia in the ciliated vacuoles/cysts, have a normal axonemal structure and may have a common origin from the basal centrioles. It is, however, unclear whether or not they are primary-like cilia. In addition, presence of the multiple basal MTOC and some morphologic features point to a high microtubule-associated vesicular transport activity and probably indicate an elevated interaction with the interstitium; thus, the cells have a different polarization then normal ciliated cells.
在研究新生仓鼠肺中的上皮-基质相互作用时，基底中心粒、基底纤毛和开放环中心粒引起了我们的注意。在3周龄的小鹿色带帽大鼠的细支气管上皮中也发现了同样的结构，这表明它们并非仓鼠肺特有的现象。虽然具有基底中心粒的细胞并不常见，但与出生后第4天相比，在出生后第二周的细支气管样本中更容易观察到它们。中心粒通常可能拥有两个卫星体，并作为微管组织中心（MTOC）发挥作用。开放环中心粒是成熟结构，也可作为MTOC。显然，三联体可能会从头添加到开放环中心粒上和/或从开放环中心粒上降解。基底纤毛以及纤毛小泡/囊肿中的纤毛，具有正常的轴丝结构，可能与基底中心粒有共同的起源。然而，它们是否为初级样纤毛尚不清楚。此外，多个基底MTOC的存在以及一些形态学特征表明微管相关的囊泡运输活动很高，可能意味着与间质的相互作用增强；因此，这些细胞的极化方式与正常纤毛细胞不同。
