Hedegaard M, Henriksen T B, Sabroe S, Secher N J
Department of Obstetrics and Gynaecology, Aarhus University Hospital, Denmark.
Acta Obstet Gynecol Scand. 1996 Jan;75(1):32-9. doi: 10.3109/00016349609033280.
Fetal growth may be determined by genetic as well as environmental factors. Whether psychological distress during pregnancy influences fetal growth is a matter of debate.
A prospective population-based study with repeated measures of psychological distress (General Health Questionnaire) during pregnancy, based on the use of questionnaires. Danish speaking women with singleton pregnancies attending antenatal care between August 1, 1989 and September 30, 1991 were eligible to the study (n = 8719). Of these women 5868 women (67%) completed all questionnaires. The main outcome measure was fetal growth (assessed as birth weight for gestational age (continuous)) and birth weight below the 10th percentile of birth weight for gestational age (light for gestational age (LGA) (dichotomous). Gestational age was calculated primarily from an early ultrasound scan. Confounders were controlled using multivariate statistical methods.
Birth weight for gestational age and risk of delivering a LGA baby were not associated with psychological distress, neither distress in 16th week nor in 30th week of pregnancy.
To the extent that fetal growth can be explored at birth, the results indicate that psychological distress does not influence fetal growth.
胎儿生长可能由遗传因素以及环境因素决定。孕期心理困扰是否会影响胎儿生长是一个存在争议的问题。
一项基于人群的前瞻性研究，通过问卷调查对孕期心理困扰（一般健康问卷）进行重复测量。1989年8月1日至1991年9月30日期间参加产前护理的丹麦语单胎妊娠妇女符合研究条件（n = 8719）。其中5868名妇女（67%）完成了所有问卷。主要结局指标是胎儿生长（以胎龄出生体重（连续变量）评估）以及胎龄出生体重低于第10百分位数（小于胎龄儿（LGA）（二分变量））。胎龄主要根据早期超声扫描计算。使用多变量统计方法控制混杂因素。
胎龄出生体重以及分娩小于胎龄儿的风险与心理困扰均无关联，无论是妊娠第16周还是第30周的困扰。
就出生时可探究的胎儿生长情况而言，结果表明心理困扰不会影响胎儿生长。
