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[头颈部皮肤癌的放射治疗]

[Radiotherapy of cutaneous cervical-facial carcinomas].

作者信息

Tordiglione M, Cerizza L, Antognoni P, Luraghi R

机构信息

Divisione di Radioterapia, Ospedale di Circolo e Fondazione Macchi, Varese.

出版信息

Acta Otorhinolaryngol Ital. 1995 Jun;15(3):168-78; discussion 179.

PMID:8561019
Abstract

The main goal of therapy for epithelial skin cancer is cure with the best functional and cosmetic outcome. Both surgery and radiotherapy give similar results for early stage lesions with 5-year local control rates ranging from 85% to 95%. Remarkable technological progress has been made yielding well defined indications to radiotherapy as a single treatment or in the context of a multidisciplinary approach. Selection of treatment should be tailored considering anatomic site, surface conformation, size, histology, grading and characteristics of tumours (new occurrence, relapse), number of localizations, age and medical conditions of the single patient. Surgery, guided by intraoperative control of resection margins, is undoubtedly the therapy of choice for most of early stage lesions. Radiation therapy plays an important role in specific anatomic situations in which the functional or cosmetic result is better than for a surgical modality, electively for the treatment of multiple lesions and for large deep- infiltrating carcinomas that generally are not suitable to excision. Exclusive radiotherapy is also indicated as rescue treatment of surgical relapses no more amenable to reexcision as well as for palliation of advanced cases, mainly for elderly or medically compromised patients. Postoperative irradiation should be considered for macro or microscopic residual disease. Merkel cell or adnexal carcinomas and for highly recurrent lesions after repeated surgery. Treatment results and complications of radiotherapy are discussed, emphasizing high local control rates and good functional and cosmetic outcomes. The main irradiation techniques referred to specific anatomic sites are also presented.

摘要

上皮性皮肤癌的主要治疗目标是实现治愈,并获得最佳的功能和美容效果。对于早期病变,手术和放疗的效果相似,5年局部控制率在85%至95%之间。在放疗作为单一治疗或多学科治疗方案的应用方面,已经取得了显著的技术进步,产生了明确的适应证。治疗方案的选择应根据解剖部位、表面形态、大小、组织学、肿瘤分级和特征(新发、复发)、病变部位数量、患者年龄和身体状况进行个体化定制。在术中对切缘进行控制的指导下,手术无疑是大多数早期病变的首选治疗方法。放射治疗在特定的解剖情况下发挥着重要作用,在这些情况下,其功能或美容效果优于手术方式,可选择性地用于治疗多发性病变以及一般不适合切除的大型深部浸润性癌。单纯放疗也适用于无法再次切除的手术复发的挽救治疗以及晚期病例的姑息治疗,主要针对老年患者或身体状况较差的患者。对于存在大体或镜下残留病灶、默克尔细胞癌或附属器癌以及多次手术后高复发风险的病变,应考虑术后放疗。本文讨论了放疗的治疗效果和并发症,强调了高局部控制率以及良好的功能和美容效果。还介绍了针对特定解剖部位的主要放疗技术。

相似文献

1
[Radiotherapy of cutaneous cervical-facial carcinomas].[头颈部皮肤癌的放射治疗]
Acta Otorhinolaryngol Ital. 1995 Jun;15(3):168-78; discussion 179.
2
[Cervicofacial neuroendocrine Merkel cell carcinoma: radiotherapy].[头颈部神经内分泌默克尔细胞癌:放射治疗]
Acta Otorhinolaryngol Ital. 1994 Nov-Dec;14(6):651-7.
3
Regarding: Rosenthal DI, Glatstein E. "We've Got a Treatment, but What's the Disease?" The Oncologist 1996;1.关于:罗森塔尔·迪、格拉茨坦·埃。《我们有了一种治疗方法,但疾病是什么?》,《肿瘤学家》1996年;第1期。
Oncologist. 1997;2(1):59-61.
4
Adjuvant local irradiation for Merkel cell carcinoma.默克尔细胞癌的辅助局部放疗。
Arch Dermatol. 2006 Jun;142(6):693-700. doi: 10.1001/archderm.142.6.693.
5
Radiotherapy alone for clinical T4 skin carcinoma of the head and neck with surgery reserved for salvage.头颈部临床T4期皮肤癌单纯放疗,手术留作挽救性治疗。
Am J Otolaryngol. 2001 Nov-Dec;22(6):387-90. doi: 10.1053/ajot.2001.28083.
6
External beam radiotherapy versus radical prostatectomy for clinical stage T1-2 prostate cancer: therapeutic implications of stratification by pretreatment PSA levels and biopsy Gleason scores.临床分期为T1-2期前列腺癌的体外放射治疗与根治性前列腺切除术:根据治疗前前列腺特异性抗原(PSA)水平和活检Gleason评分分层的治疗意义
Cancer J Sci Am. 1997 Mar-Apr;3(2):78-87.
7
Disease control, survival, and functional outcome after multimodal treatment for advanced-stage tongue base cancer.晚期舌根癌多模式治疗后的疾病控制、生存率及功能转归
Head Neck. 2004 Jul;26(7):561-72. doi: 10.1002/hed.20012.
8
[Therapeutic strategies for cutaneous carcinomas in cervical-cortical areas].[宫颈皮质区域皮肤癌的治疗策略]
Acta Otorhinolaryngol Ital. 1995 Jun;15(3):153-7; discussion 158.
9
Local control after the use of adjuvant electron beam intraoperative radiotherapy in patients with high-risk head and neck cancer: the UCSF experience.高危头颈癌患者术中使用辅助电子束放疗后的局部控制:加州大学旧金山分校的经验
Cancer J Sci Am. 1996 Nov-Dec;2(6):321-9.
10
Merkel cell carcinoma: improved outcome with adjuvant radiotherapy.默克尔细胞癌:辅助放疗改善预后。
ANZ J Surg. 2005 May;75(5):275-81. doi: 10.1111/j.1445-2197.2005.03353.x.