Tordiglione M, Cerizza L, Antognoni P, Luraghi R
Divisione di Radioterapia, Ospedale di Circolo e Fondazione Macchi, Varese.
Acta Otorhinolaryngol Ital. 1995 Jun;15(3):168-78; discussion 179.
The main goal of therapy for epithelial skin cancer is cure with the best functional and cosmetic outcome. Both surgery and radiotherapy give similar results for early stage lesions with 5-year local control rates ranging from 85% to 95%. Remarkable technological progress has been made yielding well defined indications to radiotherapy as a single treatment or in the context of a multidisciplinary approach. Selection of treatment should be tailored considering anatomic site, surface conformation, size, histology, grading and characteristics of tumours (new occurrence, relapse), number of localizations, age and medical conditions of the single patient. Surgery, guided by intraoperative control of resection margins, is undoubtedly the therapy of choice for most of early stage lesions. Radiation therapy plays an important role in specific anatomic situations in which the functional or cosmetic result is better than for a surgical modality, electively for the treatment of multiple lesions and for large deep- infiltrating carcinomas that generally are not suitable to excision. Exclusive radiotherapy is also indicated as rescue treatment of surgical relapses no more amenable to reexcision as well as for palliation of advanced cases, mainly for elderly or medically compromised patients. Postoperative irradiation should be considered for macro or microscopic residual disease. Merkel cell or adnexal carcinomas and for highly recurrent lesions after repeated surgery. Treatment results and complications of radiotherapy are discussed, emphasizing high local control rates and good functional and cosmetic outcomes. The main irradiation techniques referred to specific anatomic sites are also presented.
上皮性皮肤癌的主要治疗目标是实现治愈,并获得最佳的功能和美容效果。对于早期病变,手术和放疗的效果相似,5年局部控制率在85%至95%之间。在放疗作为单一治疗或多学科治疗方案的应用方面,已经取得了显著的技术进步,产生了明确的适应证。治疗方案的选择应根据解剖部位、表面形态、大小、组织学、肿瘤分级和特征(新发、复发)、病变部位数量、患者年龄和身体状况进行个体化定制。在术中对切缘进行控制的指导下,手术无疑是大多数早期病变的首选治疗方法。放射治疗在特定的解剖情况下发挥着重要作用,在这些情况下,其功能或美容效果优于手术方式,可选择性地用于治疗多发性病变以及一般不适合切除的大型深部浸润性癌。单纯放疗也适用于无法再次切除的手术复发的挽救治疗以及晚期病例的姑息治疗,主要针对老年患者或身体状况较差的患者。对于存在大体或镜下残留病灶、默克尔细胞癌或附属器癌以及多次手术后高复发风险的病变,应考虑术后放疗。本文讨论了放疗的治疗效果和并发症,强调了高局部控制率以及良好的功能和美容效果。还介绍了针对特定解剖部位的主要放疗技术。