Yurgelun-Todd D A, Waternaux C M, Cohen B M, Gruber S A, English C D, Renshaw P F
McLean Brain Imaging Center, Belmont, MA 02178, USA.
Am J Psychiatry. 1996 Feb;153(2):200-5. doi: 10.1176/ajp.153.2.200.
This study was undertaken to test the feasibility of using functional magnetic resonance imaging (MRI) to examine changes in cortical activation in response to verbal tasks in two brain regions.
Twelve schizophrenic patients and 11 comparison subjects underwent functional MRI of the frontal and temporal lobes. Stimulus sequences were divided into five 30-second segments by using a task-activation paradigm that alternated between resting and stimulated states. Functional images were collected every 30 seconds by using a gradient echo pulse sequence.
Schizophrenic subjects demonstrated significantly less left frontal activation and greater left temporal activation than comparison subjects during a word fluency task.
These preliminary data suggest that functional MRI has the sensitivity to detect differences in activation between comparison subjects and schizophrenic patients during higher cortical functions. These findings are in agreement with PET studies that reported reduced left frontal activation during challenge paradigms for the schizophrenic patients.
本研究旨在测试使用功能磁共振成像（MRI）检查两个脑区对言语任务的皮质激活变化的可行性。
12名精神分裂症患者和11名对照受试者接受了额叶和颞叶的功能MRI检查。使用在静息和刺激状态之间交替的任务激活范式，将刺激序列分为五个30秒的片段。使用梯度回波脉冲序列每30秒采集一次功能图像。
在词语流畅性任务中，精神分裂症受试者的左额叶激活明显少于对照受试者，而左颞叶激活则多于对照受试者。
这些初步数据表明，功能MRI具有检测对照受试者和精神分裂症患者在高级皮质功能期间激活差异的敏感性。这些发现与PET研究一致，PET研究报告称精神分裂症患者在挑战范式期间左额叶激活减少。
