Greiner P A, Snowdon D A, Schmitt F A
University of Kentucky, Sanders-Brown Center on Aging, Lexington 40536-0230, USA.
Am J Public Health. 1996 Jan;86(1):62-6. doi: 10.2105/ajph.86.1.62.
This study investigated the role of low normal cognitive function in the subsequent loss of independence in activities of daily living.
Of the 678 elderly nuns who-completed cognitive and physical function assessments in 1992/93, 575 were reassessed in 1993/94. Mini-Mental State Examination scores were divided into three categories and related to loss of independence in six activities of daily living.
Participants with low normal cognitive function at first assessment had twice the risk of losing independence in three activities of daily living by second assessment relative to those with high normal cognitive function. This relationship was largely due to a progression from low normal cognitive function at first assessment to impaired cognitive function at second assessment and was associated with an elevated risk of losing independence in the six activities.
Progression from low normal to impaired cognitive function was associated with loss of independence in activities of daily living. Thus low normal cognitive function could be viewed as an early warning of impending cognitive impairment and loss of physical function.
本研究调查了轻度认知功能正常在随后日常生活活动能力丧失中的作用。
在1992/93年完成认知和身体功能评估的678名老年修女中，575名在1993/94年接受了重新评估。简易精神状态检查表得分被分为三类，并与六项日常生活活动中的独立性丧失相关。
首次评估时轻度认知功能正常的参与者在第二次评估时，相对于认知功能高度正常的参与者，在三项日常生活活动中丧失独立性的风险是其两倍。这种关系很大程度上是由于从首次评估时的轻度认知功能正常进展到第二次评估时的认知功能受损，并与六项活动中丧失独立性的风险升高相关。
从轻度认知功能正常进展到认知功能受损与日常生活活动能力丧失相关。因此，轻度认知功能正常可被视为即将发生认知障碍和身体功能丧失的早期预警。
