Kang Weixi, Whelan Edward, Malvaso Antonio
Imperial College London, London SW7 2BX, UK.
Independent Researcher, 99MX QH Maynooth, County Kildare, Ireland.
Healthcare (Basel). 2023 May 6;11(9):1337. doi: 10.3390/healthcare11091337.
Cognitive deficits are commonly seen in people with arthritis. However, previous studies focused primarily on small-sized clinical samples. There is a need for cohort-based studies, which are characterized by high generalizability. In addition, these studies mainly focused on attention, memory, and executive function. However, cognition is not a single concept, but includes other cognitive domains, such as verbal fluency and arithmetic abilities. Thus, we aim to explore how arthritis can affect cognitive abilities, including episodic memory, semantic verbal fluency, fluid reasoning, and numerical ability by using a large cohort from the United Kingdom. The main findings were that people with arthritis have significantly lower immediate word recall (t(2257) = -6.40, < 0.001, Cohen's d = -0.12, 95% C.I. = [-0.16, -0.08]), delayed word recall (t(2257) = -5.60, < 0.001, Cohen's d = -0.11, 95% C.I. = [-0.14, -0.07]), semantic verbal fluency (t(2257) = -3.03, < 0.01, Cohen's d = -0.06, 95% C.I. = [-0.10, -0.02]), fluid reasoning (t(2257) = -3.96, < 0.001, Cohen's d = -0.07, 95% C.I. = [-0.11, -0.04]), and numerical ability (t(2257) = -3.85, < 0.001, Cohen's d = -0.07, 95% C.I. = [-0.10, -0.03]) compared to what they would expect given their demographics. Interventions are needed to improve cognitive abilities in people with arthritis.
认知缺陷在关节炎患者中很常见。然而，以往的研究主要集中在小样本的临床研究上。有必要开展基于队列的研究，这类研究具有高度的普遍性。此外，这些研究主要关注注意力、记忆力和执行功能。然而，认知并非一个单一的概念，还包括其他认知领域，如语言流畅性和算术能力。因此，我们旨在通过使用来自英国的一个大型队列，探索关节炎如何影响认知能力，包括情景记忆、语义语言流畅性、流体推理和数字能力。主要研究结果表明，与根据其人口统计学特征预期的情况相比，关节炎患者的即时单词回忆能力（t(2257) = -6.40，p < 0.001，Cohen's d = -0.12，95%置信区间 = [-0.16, -0.08]）、延迟单词回忆能力（t(2257) = -5.60，p < 0.001，Cohen's d = -0.11，95%置信区间 = [-0.14, -0.07]）、语义语言流畅性（t(2257) = -3.03，p < 0.01，Cohen's d = -0.06，95%置信区间 = [-0.10, -0.02]）、流体推理能力（t(2257) = -3.96，p < 0.001，Cohen's d = -0.07，95%置信区间 = [-0.11, -0.04]）和数字能力（t(2257) = -3.85，p < 0.001，Cohen's d = -0.07，95%置信区间 = [-0.10, -0.03]）均显著较低。需要采取干预措施来提高关节炎患者的认知能力。
