Deloron P, Aubry P, Ndayirabije A, Clavier F, Verdier F
Institut Natiional de la Sante et de la Recherche Medicale (INSERM) Unite 13, Institut de Medecine et d'Epidemiologie Africaines (IMEA), Paris, France.
Am J Trop Med Hyg. 1995 Dec;53(6):646-7. doi: 10.4269/ajtmh.1995.53.646.
Twenty-four patients presenting with severe Plasmodium falciparum infection at the Kamenge Hospital in Burundi were enrolled in a double-blind study comparing the efficacy of a seven-day regimen of intravenous quinine alone or in combination with pefloxacin. The aim of this study was to assess whether pefloxacin modified chloroquine efficacy or its uptake by infected erythrocytes as shown with other antimalarials. Pefloxacin did not modify the antimalarial activity of quinine, in terms of speed of parasite or fever clearance. Moreover, pefloxacin does not appear to interact with quinine uptake by erythrocytes in humans.
24名在布隆迪卡门盖医院患有严重恶性疟原虫感染的患者参与了一项双盲研究，该研究比较了单独静脉注射奎宁七天疗程或与培氟沙星联合使用的疗效。本研究的目的是评估培氟沙星是否像其他抗疟药那样改变氯喹的疗效或其被感染红细胞摄取的情况。就寄生虫清除速度或退热速度而言，培氟沙星并未改变奎宁的抗疟活性。此外，培氟沙星似乎不会与人红细胞摄取奎宁发生相互作用。
