Despatis M A, Carrier M, Pelletier L C
Département de Chirurgie, Institut de Cardiologie de Montréal, Québec, Canada.
Ann Chir. 1995;49(8):706-11.
We have studied the effect of cyclosporin on the peripheral venous system. CSA was injected into an isolated hind limb saphenous vein perfused at constant flow in 29 dogs. Reactivity of the vein was tested with infusions of norepinephrine (NE) before and after CSA. In a 1st group of 7 dogs, CSA at doses of 5, 10 and 20 mg was infused over a 10-minute period. In a 2nd group of 8 dogs, 20 mg of CSA was infused over 20 minutes and, injections of 6, 12 and 24 micrograms of NE were administered before and during CSA. In a 3rd (n = 7) and 4th (n = 7) groups of animals, 30 mg of CSA was injected over 60 minutes and injections of 3, 6, 12 micrograms of NE were given before and during CSA. In the last group, an ipsilateral lumbar sympathectomy was performed before CSA injection. The infusion of CSA over periods of 10 and 20 minutes did not cause significant changes in venous perfusion pressure. The infusion of 30 mg of CSA over 60 minutes caused an increase in venous perfusion pressure from 44 +/- 2 mm Hg to 58 +/- 5 mm Hg (p < 0.0001). Surgical sympathectomy prevented the venoconstrictor response to CSA. Injections of 3, 6 and 12 +/- g of NE caused averaged increases of 25 +/- 6, 39 +/- 9 and 53 +/- 10 mm Hg before CSA, and of 45 +/- 7, 69 +/- 12 and 84 +/- 8 mm Hg respectively after CSA injections, a significant increase (p = 0.03). In conclusion, CSA causes a vasoconstriction of the saphenous vein through stimulation of the sympathetic nervous system and potentiates the venoconstrictor effect of NE.
我们研究了环孢素对周围静脉系统的影响。将环孢素A（CSA）注入29只狗的离体后肢隐静脉，该静脉以恒定流量灌注。在注入CSA前后，通过输注去甲肾上腺素（NE）来测试静脉的反应性。在第一组7只狗中，在10分钟内输注剂量为5、10和20mg的CSA。在第二组8只狗中，在20分钟内输注20mg的CSA，并在输注CSA之前和期间注射6、12和24微克的NE。在第三组（n = 7）和第四组（n = 7）动物中，在60分钟内注射30mg的CSA，并在注射CSA之前和期间注射3、6、12微克的NE。在最后一组中，在注射CSA之前进行同侧腰交感神经切除术。在10和20分钟内输注CSA不会引起静脉灌注压的显著变化。在60分钟内输注30mg的CSA会使静脉灌注压从44±2mmHg增加到58±5mmHg（p < 0.0001）。手术交感神经切除术可防止对CSA的静脉收缩反应。注射3、6和12μg的NE在注射CSA之前平均使血压升高25±6、39±9和53±10mmHg，在注射CSA之后分别升高45±7、69±12和84±8mmHg，有显著增加（p = 0.03）。总之，CSA通过刺激交感神经系统引起隐静脉血管收缩，并增强NE的静脉收缩作用。
