Nakamura F, Suyama K
Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Arch Biochem Biophys. 1996 Jan 15;325(2):167-73. doi: 10.1006/abbi.1996.0021.
A novel amino acid named aldosine was isolated from acid hydrolysates of bovine aorta elastin. The mass spectral analysis of aldosine indicated a parent compound with a mass of 256 (C12H20N2O4). From the structure identified by spectroscopy of aldosine and its derivatives, it was deduced that aldosine was derived from aldol crosslink and dehydromerodesmosine of elastin and collagen. The aldosine content in aorta of newborn rats was very low, but increased markedly with growth. After maturity was reached, the aldosine content decreased. The aldosine content in bovine aorta decreased gradually from 7 months to 16 years of age. Aldosine was also quantified in the aorta and tail tendon of rats in two models of hyperglycemia: diabetes and galactosemia. Hyperglycemias were significantly affected on aldosine content of organs. In both diabetic and galactosemic animals, aldosine was remarkably lower relative to controls (about one-half and one-sixth, respectively).
一种名为醛糖素的新型氨基酸是从牛主动脉弹性蛋白的酸水解产物中分离出来的。醛糖素的质谱分析表明其母体化合物质量为256（C12H20N2O4）。根据醛糖素及其衍生物的光谱鉴定结构推断，醛糖素源自弹性蛋白和胶原蛋白的醛醇交联以及脱氢异锁链素。新生大鼠主动脉中的醛糖素含量非常低，但随着生长显著增加。达到成熟后，醛糖素含量下降。牛主动脉中的醛糖素含量从7个月到16岁逐渐降低。在两种高血糖模型（糖尿病和半乳糖血症）的大鼠主动脉和尾腱中也对醛糖素进行了定量分析。高血糖对器官中的醛糖素含量有显著影响。在糖尿病动物和半乳糖血症动物中，醛糖素相对于对照组均显著降低（分别约为对照组的二分之一和六分之一）。
