Slemons R D, Swayne D E
Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Ohio State University, Columbus 43210-1093, USA.
Avian Dis. 1995 Jul-Sep;39(3):521-7.
Waterfowl-origin influenza (WFOI) viruses were evaluated for their tissue tropism and replicative properties in chickens. The 14 WFOI isolates used in this study represented 13 different hemagglutinin-neuraminidase combinations recovered during 1987 and 1988 and included isolates possessing the H5 and H7 hemagglutinin subtypes and one isolate possessing the H5N2 combination. Following intravenous challenge, the frequencies of virus recovery within individual experiments were generally higher for the lower digestive tract and kidney samples. Virus titers ranged up to 10(8.5) mean embryo infective doses per gram of kidney tissue in clinically normal chickens. Differences in frequencies of virus recovery and virus titers in tissues indicated that some of these uniformly nonpathogenic and low-pathogenicity WFOI virus isolates replicated more extensively in chickens than did others. This enhanced ability to replicate in chickens should be further evaluated as a potential factor associated with the threat WFOI viruses present to poultry.
对源自水禽的流感（WFOI）病毒在鸡体内的组织嗜性和复制特性进行了评估。本研究中使用的14株WFOI分离株代表了1987年和1988年期间获得的13种不同的血凝素 - 神经氨酸酶组合，包括具有H5和H7血凝素亚型的分离株以及一株具有H5N2组合的分离株。静脉注射攻毒后，在各个实验中，下消化道和肾脏样本中病毒回收的频率通常更高。在临床正常的鸡中，病毒滴度高达每克肾脏组织10（8.5）平均胚胎感染剂量。组织中病毒回收频率和病毒滴度的差异表明，这些均为非致病性和低致病性的WFOI病毒分离株中的一些在鸡体内的复制比其他分离株更广泛。这种在鸡体内增强的复制能力应作为与WFOI病毒对家禽构成的威胁相关的潜在因素进一步评估。
