Lloyd C, Hafner R J, Holme G
Dibden Research Unit, Glenside Hospital, Eastwood, Australia.
J Geriatr Psychiatry Neurol. 1995 Oct;8(4):213-6. doi: 10.1177/089198879500800403.
Fifty-seven subjects with moderate to severe dementia (49 with Alzheimer's disease) were rated twice, 8 weeks apart, using the Mini-Mental State Examination (MMSE), the Blessed Information-Memory-Concentration Test (BIMC), and the Stockton Geriatric Rating Scale (SGRC). Only three subjects lived at home; the rest were in long-stay hospital beds or nursing homes. For 29 subjects, the first rating coincided with their referral to a comprehensive geriatric psychiatry service. The main hypothesis, that the level of behavioral disturbance would correlate positively with the level of cognitive impairment, was strongly confirmed. This finding may reflect the severity of dementia in the study sample. The correlations between MMSE and BIMC scores were .87 at entry and .92 at exit, suggesting that the two measures were broadly equivalent, although both had marked floor effects. Test-retest reliability was high for all three measures. Overall, medication was of limited effectiveness in managing severe behavioral disturbance, highlighting the need for introducing effective behavioral programs.
57名患有中度至重度痴呆症的受试者（49名患有阿尔茨海默病），相隔8周接受了两次评估，评估采用简易精神状态检查表（MMSE）、Blessed信息-记忆-注意力测试（BIMC）以及斯托克顿老年评定量表（SGRC）。只有3名受试者居家生活，其余的都住在长期住院病床或养老院。对于29名受试者而言，首次评估与他们被转介至综合老年精神病学服务机构的时间一致。行为障碍水平与认知障碍水平呈正相关这一主要假设得到了有力证实。这一发现可能反映了研究样本中痴呆症的严重程度。MMSE和BIMC分数之间的相关性在入组时为0.87，在退出时为0.92，这表明这两种测量方法大致等效，尽管两者都有明显的下限效应。所有三种测量方法的重测信度都很高。总体而言，药物在控制严重行为障碍方面效果有限，这凸显了引入有效行为项目的必要性。
