Ladd A, Walfield A, Tsong Y Y, Thau R
Population Council, Center for Biomedical Research, New York, New York, USA.
Am J Reprod Immunol. 1995 Sep;34(3):200-6. doi: 10.1111/j.1600-0897.1995.tb00939.x.
To determine whether active immunization against LHRH can serve as treatment for androgen-dependent prostatic carcinoma.
Male rats of Copenhagen X Fisher strain, implanted with Dunning R-3327 prostatic carcinoma cells were either immunized against LHRH, treated with LHRH-antagonist, or received a combined treatment of active immunization against LHRH and LHRH-antagonist.
Testicular histology was consistent with infertility in all treatment groups. The rate of tumor growth was inhibited by all three treatment regimens. Tumor size increased by 3.8 +/- 1.4 cm2 in the LHRH-antagonist group, 3.2 +/- 1.1 cm2 in the immunized group, and 1.0 +/- 0.4 cm2 in the combined treatment group, as compared to 8.2 +/- 2.6 cm2 in non-treated control group.
LHRH-antagonist administration combined with immunization against LHRH appeared to exert a synergistic effect. This may be due to the blockade of prostatic LHRH-like receptors by the antagonist, while androgen depletion was rapidly achieved by LHRH-antagonist, and maintained by continued gonadotropin suppression caused by active immunization against LHRH once antagonist treatment had been discontinued.
确定针对促黄体生成素释放激素（LHRH）的主动免疫是否可作为雄激素依赖性前列腺癌的治疗方法。
将接种了邓宁R-3327前列腺癌细胞的哥本哈根X费舍尔品系雄性大鼠，分别进行针对LHRH的免疫、用LHRH拮抗剂治疗，或接受针对LHRH的主动免疫与LHRH拮抗剂的联合治疗。
所有治疗组的睾丸组织学表现均与不育相符。所有三种治疗方案均抑制了肿瘤生长速度。与未治疗的对照组肿瘤面积增加8.2±2.6平方厘米相比，LHRH拮抗剂组肿瘤面积增加3.8±1.4平方厘米，免疫组增加3.2±1.1平方厘米，联合治疗组增加1.0±0.4平方厘米。
给予LHRH拮抗剂并联合针对LHRH的免疫似乎产生了协同作用。这可能是由于拮抗剂阻断了前列腺中类似LHRH的受体，而LHRH拮抗剂可迅速实现雄激素耗竭，且在拮抗剂治疗停止后，通过针对LHRH的主动免疫持续抑制促性腺激素来维持雄激素耗竭状态。
