Kintz P, Marescaux C, Mangin P
Institut de Médecine Légale, Strasbourg, France.
Hum Exp Toxicol. 1995 Oct;14(10):812-5. doi: 10.1177/096032719501401006.
Hair samples were obtained from 30 patients who had been taking carbamazepine in fixed daily doses for more than 6 months. Carbamazepine was extracted from the hair by enzymatic hydrolysis and quantified by gas chromatography-mass spectrometry. Concentrations ranged from 1.2 to 57.4 ng mg-1. The concentrations of carbamazepine were significantly correlated (P < 0.0001) with the daily dose and the correlation coefficient was 0.793. Although it had been suggested by several authors that the measurement of carbamazepine in hair might provide a better index of individual dosage history than the plasma level assays, the deviations observed in this study led to the conclusion that hair samples are not suitable for evaluating the quantity of drug consumed. However, hair testing may be useful for documenting clinical disorders by sectioning the shaft into segments corresponding to 1 month periods.
从30名患者身上采集了头发样本，这些患者每天服用固定剂量的卡马西平超过6个月。通过酶水解从头发中提取卡马西平，并采用气相色谱 - 质谱法进行定量。浓度范围为1.2至57.4 ng mg-1。卡马西平的浓度与每日剂量显著相关（P < 0.0001），相关系数为0.793。尽管有几位作者提出，与血浆水平检测相比，检测头发中的卡马西平可能能更好地反映个体用药史，但本研究中观察到的偏差得出结论：头发样本不适合用于评估药物摄入量。然而，通过将发干切成对应于1个月时间段的片段，头发检测可能有助于记录临床疾病。
