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[骨质疏松性骨折的流行病学]

[The epidemiology of osteoporotic fractures].

作者信息

Sartori L, Maggi S

机构信息

Istituto di Medicina Interna, Università degli Studi di Padova.

出版信息

Ann Ital Med Int. 1995 Oct;10 Suppl:5S-8S.

PMID:8562267
Abstract

Fractures represent the most important consequence of osteoporosis, as well as the major determinant of the socio-economic costs of the disease. Distal forearm, vertebrae and proximal femur fractures are frequently associated with the disease. Colles' fractures generally occur in women, showing a progressive increase in incidence after the onset of menopause, and reaching a plateau at the age of 65 years. Vertebral fractures are often painless and fortuitously diagnosed so that there are not many epidemiological data available. However, incidence rates appear to increase steadily with aging in women, while accelerating only in later life in men. In the elderly population, spine deformities due to vertebral fractures can contribute to the worsening of concurrent diseases. Fractures of the proximal femur represent the gold standard for epidemiological studies on osteoporosis. Their incidence increases exponentially in women 70 years old and over, and in men aged 80 or older. Moreover, that, femoral fractures are associated with a substantial risk of nonself sufficiency and mortality. Osteoporosis-related costs vary greatly among countries, not only because of a different incidence of the disease, but also due to the different emphasis on prevention, hospitalization, and treatment. The current dramatic increase of the elderly population exhorts against the postponing of a global strategy for preventing and treating the disease.

摘要

骨折是骨质疏松症最重要的后果,也是该疾病社会经济成本的主要决定因素。前臂远端、椎骨和股骨近端骨折常与该疾病相关。科勒斯骨折通常发生在女性身上,在绝经后发病率逐渐上升,并在65岁时达到平稳状态。椎体骨折通常无痛,多为偶然诊断,因此可用的流行病学数据不多。然而,女性的发病率似乎随着年龄增长而稳步上升,而男性仅在晚年才加速上升。在老年人群中,椎体骨折导致的脊柱畸形会促使并发疾病恶化。股骨近端骨折是骨质疏松症流行病学研究的金标准。在70岁及以上的女性和80岁及以上的男性中,其发病率呈指数级增长。此外,股骨骨折会带来相当大的生活不能自理风险和死亡风险。骨质疏松症相关的成本在各国之间差异很大,这不仅是因为该疾病的发病率不同,还由于对预防、住院治疗和治疗的重视程度不同。当前老年人口的急剧增加敦促人们不要推迟制定预防和治疗该疾病的全球战略。

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