De Laet C E, Pols H A
Institute for Medical Technology Assessment, Erasmus University, Rotterdam, The Netherlands.
Baillieres Best Pract Res Clin Endocrinol Metab. 2000 Jun;14(2):171-9. doi: 10.1053/beem.2000.0067.
Osteoporosis and osteoporosis-related fractures are a major source of both morbidity and cost in the elderly, the fractures that are most commonly associated with osteoporosis being those of the hip, the distal forearm and the vertebrae, although it is believed that most other fractures occurring in the elderly are also related to osteoporosis. In this review, the incidence of all types of fracture is described based on the available literature, and the foreseeable trends resulting from demographic changes are discussed. Emphasis is given to the epidemiology of hip fracture since this is the most serious consequence of osteoporosis. Hip fractures occur all over the world, most currently occurring in Western countries, mainly Europe and the USA, but it is expected that there will be a large increase in the number of hip fractures in other countries because of demographic changes. The incidence of hip fractures increases exponentially with age, resulting in a 1-year incidence of 1% in women aged 80 in Western countries. Most hip fractures occur in women, but this is again partly due to demography, because of the longer life expectancy of women. Wrist fractures occur more often in women and do not show the same increase with age as hip fractures. The incidence reaches a plateau at age 60-70. Vertebral fractures show a modest increase with age and are again more common in women than men. The incidence of all other fractures increases modestly with age
骨质疏松症及与骨质疏松症相关的骨折是老年人发病和花费的主要原因。与骨质疏松症最常相关的骨折是髋部、前臂远端和脊椎骨折,不过据信老年人发生的大多数其他骨折也与骨质疏松症有关。在本综述中,基于现有文献描述了所有类型骨折的发病率,并讨论了人口结构变化所导致的可预见趋势。重点阐述了髋部骨折的流行病学,因为这是骨质疏松症最严重的后果。髋部骨折在世界各地均有发生,目前大多数发生在西方国家,主要是欧洲和美国,但由于人口结构变化,预计其他国家的髋部骨折数量将大幅增加。髋部骨折的发病率随年龄呈指数增长,在西方国家80岁女性中的年发病率为1%。大多数髋部骨折发生在女性身上,但这同样部分归因于人口结构,因为女性的预期寿命更长。腕部骨折在女性中更为常见,且不像髋部骨折那样随年龄增加。发病率在60 - 70岁时达到平稳状态。椎体骨折随年龄有适度增加,同样在女性中比男性更常见。所有其他骨折的发病率随年龄适度增加