Nicholson I R, Chapman J E, Neufeld R W
Department of Psychiatry, Victoria Hospital, London, Ont., Canada.
Schizophr Res. 1995 Oct;17(2):177-85. doi: 10.1016/0920-9964(94)00088-p.
Reviewing Brief Psychiatric Rating Scale (BPRS) research indicates that combining items to form larger 'symptom factors' (e.g., depression, psychosis) has become the standard methodology. Unfortunately, a single symptom factor may be defined by different combinations of different BPRS items in different studies. To examine the potential impact of these differences, a number of different BPRS definitions of positive and negative symptoms in schizophrenia were culled from previous research. To compare these definitions, one hundred schizophrenics were interviewed with regard to current and recent symptomatology and rated on the BPRS, the Schedule for the Assessment of Negative Symptoms (SANS), and the Schedule for the Assessment of Positive Symptoms (SAPS). The four BPRS negative symptom definitions all correlated highly with one another and with the SANS. There were no differences in the amount that these different definitions of negative symptoms correlated with the SANS. Also, the nine definitions of positive symptoms all correlated highly with one another and with the SAPS. However, there were significant differences in how they correlated with the SAPS. Because of these differences, possible standard definitions for negative and positive symptoms of schizophrenia are proposed for future use of the BPRS in research.
对简明精神病评定量表（BPRS）的研究综述表明，将各个项目组合以形成更大的“症状因子”（例如，抑郁、精神病性症状）已成为标准方法。不幸的是，在不同研究中，单一症状因子可能由不同的BPRS项目组合来定义。为了检验这些差异的潜在影响，从先前的研究中挑选出了一些关于精神分裂症阳性和阴性症状的不同BPRS定义。为了比较这些定义，对100名精神分裂症患者就当前及近期症状进行了访谈，并使用BPRS、阴性症状评定量表（SANS）和阳性症状评定量表（SAPS）进行评分。四种BPRS阴性症状定义之间以及与SANS之间均高度相关。这些不同的阴性症状定义与SANS的相关程度没有差异。此外，九种阳性症状定义之间以及与SAPS之间均高度相关。然而，它们与SAPS的相关方式存在显著差异。鉴于这些差异，针对未来BPRS在研究中的使用，提出了精神分裂症阴性和阳性症状的可能标准定义。
