Montvidas Jonas, Adomaitienė Virginija, Leskauskas Darius, Dollfus Sonia
Psychiatry Department, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania.
Psychiatry Department, University of Caen Normandy, 14000 Caen, France.
J Clin Med. 2023 Jan 23;12(3):901. doi: 10.3390/jcm12030901.
(1) Background: Schizophrenia is a severe mental disorder characterized by various symptom groups that tremendously affect health-related quality of life (HRQoL). We aimed to specify whether negative symptoms and cognitive deficits of schizophrenia correlate and can predict HRQoL. (2) Methods: Patients diagnosed with paranoid schizophrenia were invited to participate in the study. Participants were evaluated using the Montreal Cognitive Assessment (MoCA) and the Brief Psychiatric Rating Scale (BPRS) and were asked to fill out the Self-evaluation of Negative Symptoms scale (SNS) and the Medical Outcomes Short Form Survey (SF-36). Pearson's and Spearman's correlations were used to calculate the correlations between cognitive deficits and negative symptoms. We performed the receiver operating characteristic (ROC) analysis for the variables correlated with SF-36 scores. (3) Results: HRQoL correlated significantly with the negative symptoms; however, it did not correlate with cognitive deficits. ROC analysis showed that the abulia subscore of the SNS showed the most significant predictive potential of HRQoL. (4) Conclusions: Negative symptoms correlate more significantly with the HRQoL than cognitive symptoms. The SNS offers the possibility of predicting the HRQoL of patients with schizophrenia and is useful as a screening tool in clinical practice.
(1) 背景：精神分裂症是一种严重的精神障碍，其特征是多种症状群，极大地影响与健康相关的生活质量（HRQoL）。我们旨在明确精神分裂症的阴性症状和认知缺陷是否相关以及能否预测HRQoL。(2) 方法：邀请被诊断为偏执型精神分裂症的患者参与研究。使用蒙特利尔认知评估量表（MoCA）和简明精神病评定量表（BPRS）对参与者进行评估，并要求他们填写阴性症状自评量表（SNS）和医学结局简明调查量表（SF - 36）。采用Pearson相关系数和Spearman相关系数计算认知缺陷与阴性症状之间的相关性。我们对与SF - 36评分相关的变量进行了受试者工作特征（ROC）分析。(3) 结果：HRQoL与阴性症状显著相关；然而，它与认知缺陷无关。ROC分析表明，SNS的意志缺乏子量表对HRQoL具有最显著的预测潜力。(4) 结论：阴性症状与HRQoL的相关性比认知症状更显著。SNS为预测精神分裂症患者的HRQoL提供了可能，并且在临床实践中作为一种筛查工具很有用。
