白内障手术前使用丙泊酚进行低剂量静脉镇静期间眼压的变化。
Changes in intraocular pressure during low dose intravenous sedation with propofol before cataract surgery.
作者信息
Neel S, Deitch R, Moorthy S S, Dierdorf S, Yee R
机构信息
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, USA.
出版信息
Br J Ophthalmol. 1995 Dec;79(12):1093-7. doi: 10.1136/bjo.79.12.1093.
AIMS
This study examined the effects on intraocular pressure, pulse rate, and blood pressure of low dose intravenous sedation with propofol.
METHODS
Twenty adult patients who were scheduled to undergo cataract surgery were given a single intravenous bolus (0.98 (SEM 0.4) mg/kg) of propofol for sedation before administering the local anaesthetic for cataract surgery. A small intravenous dose of lignocaine was the only other anaesthetic or sedative agent given. The intraocular pressure in the non-surgery eye, the pulse rate, and the blood pressure were measured before and after propofol induction.
RESULTS
Compared with the preinduction baseline, there was a 17% to 27% (from 16.2 (0.7) mm Hg to 11.8 (0.7) mm Hg) decrease in intraocular pressure after propofol induction. A significant decrease in intraocular pressure occurred within the first minute and was still evident at 7 minutes when the measurements were stopped. There was also a 7%-12% increase in pulse rate during the first 4 minutes, a 12% decrease in mean systolic blood pressure, and a 7% decrease in mean diastolic blood pressure from baseline after propofol induction.
CONCLUSION
A single low dose bolus of propofol used for sedation before cataract surgery caused a moderate reduction in intraocular pressure with minimal, easily managed side effects.
目的
本研究探讨了丙泊酚低剂量静脉镇静对眼压、脉搏率和血压的影响。
方法
20例计划接受白内障手术的成年患者，在给予白内障手术局部麻醉前，静脉推注单次剂量的丙泊酚（0.98（标准误0.4）mg/kg）进行镇静。仅给予小剂量静脉注射利多卡因作为其他麻醉或镇静剂。在丙泊酚诱导前后测量非手术眼的眼压、脉搏率和血压。
结果
与诱导前基线相比，丙泊酚诱导后眼压降低了17%至27%（从16.2（0.7）mmHg降至11.8（0.7）mmHg）。眼压在第一分钟内显著降低，在停止测量的7分钟时仍很明显。丙泊酚诱导后，前4分钟脉搏率也增加了7%-12%，平均收缩压降低了12%，平均舒张压比基线降低了7%。
结论
白内障手术前单次使用低剂量丙泊酚推注进行镇静可使眼压适度降低，且副作用最小且易于处理。
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