Naundorf H, Zschiesche W, Reszka R, Fichtner I
Laboratory of Experimental Tumor Therapy, Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany.
In Vivo. 1995 May-Jun;9(3):247-51.
A panel of 4 human mammary carcinomas passaged in nude mice were subjected to intraperitoneal application of cholesterol-free liposomes enriched with linoleic (unsaturated fatty acid) or stearic acid (saturated fatty acid). The liposomes were examined with regard to their influence on the tumor growth and level of heart type fatty acid binding protein (FABP). Liposomes with different fatty acid composition influenced the growth of mammary carcinomas 3366, BO, 4000 and 4151 in distinct ways. Liposomes with a high content of stearic acid significantly inhibited the growth of mammary carcinomas 3366 and BO, whereas mammary carcinomas 4000 and 4151 were not affected. The growth of mammary carcinoma 3366 was moderately increased after supplementation of liposomes rich in linoleic acid, the tumor BO was significantly inhibited and the growth of MaCa 4000 and 4151 was unchanged. Liposome treatment led to a significant increase in heart type FABP in mammary carcinomas 3366 and BO regardless of whether the animals were treated with liposomes rich in stearic or linoleic acid. Such significant changes of FABP level could not be observed in mammary carcinomas 4000 or 4151. We suggest that the lipid-mediated growth modulation seems to be dependent on an increase of heart type FABPs in these tumor models.
将4种在裸鼠体内传代的人乳腺癌细胞系进行腹膜内注射，分别给予富含亚油酸（不饱和脂肪酸）或硬脂酸（饱和脂肪酸）的无胆固醇脂质体。研究了这些脂质体对肿瘤生长以及心脏型脂肪酸结合蛋白（FABP）水平的影响。不同脂肪酸组成的脂质体对乳腺癌细胞系3366、BO、4000和4151的生长有不同影响。硬脂酸含量高的脂质体显著抑制乳腺癌细胞系3366和BO的生长，而乳腺癌细胞系4000和4151不受影响。补充富含亚油酸的脂质体后，乳腺癌细胞系3366的生长适度增加，肿瘤BO受到显著抑制，而MaCa 4000和4151的生长没有变化。无论动物接受富含硬脂酸还是亚油酸的脂质体治疗，脂质体处理均导致乳腺癌细胞系3366和BO中心脏型FABP显著增加。在乳腺癌细胞系4000或4151中未观察到FABP水平的这种显著变化。我们认为，在这些肿瘤模型中，脂质介导的生长调节似乎依赖于心脏型FABP的增加。
