Schaap F G, van der Vusse G J, Glatz J F
Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands.
Mol Cell Biochem. 1998 Mar;180(1-2):43-51.
Long-chain fatty acids are important fuel molecules for the heart, their oxidation in mitochondria providing the bulk of energy required for cardiac functioning. The low solubility of fatty acids in aqueous solutions impairs their cellular transport. However, cardiac tissue contains several proteins capable of binding fatty acids non-covalently. These fatty acid-binding proteins (FABPs) are thought to facilitate both cellular uptake and intracellular transport of fatty acids. The majority of fatty acids taken up by the heart seems to pass the sarcolemma through a carrier-mediated translocation mechanism consisting of one or more membrane-associated FABPs. Intracellular transport of fatty acids towards sites of metabolic conversion is most likely accomplished by cytoplasmic FABPs. In this review, the roles of membrane-associated and cytoplasmic FABPs in cardiac fatty acid metabolism under (patho)physiological circumstances are discussed.
长链脂肪酸是心脏重要的燃料分子，它们在线粒体中的氧化作用为心脏功能提供了大部分所需能量。脂肪酸在水溶液中的低溶解度会损害其细胞转运。然而，心脏组织含有几种能够非共价结合脂肪酸的蛋白质。这些脂肪酸结合蛋白（FABP）被认为有助于脂肪酸的细胞摄取和细胞内转运。心脏摄取的大部分脂肪酸似乎通过由一种或多种膜相关FABP组成的载体介导的转运机制穿过肌膜。脂肪酸向代谢转化部位的细胞内转运很可能是由细胞质FABP完成的。在这篇综述中，将讨论膜相关和细胞质FABP在（病理）生理情况下心脏脂肪酸代谢中的作用。
