Testoni P, Colombo E, Scelsi R, Cattani L, Bagnolo F, Lella F, Buizza M, Luinetti O
Istituto di Medicina Interna, Università degli Studi di Milano, Italy.
Ital J Gastroenterol. 1995 Jul-Aug;27(6):285-90.
The role played by Helicobacter pylori (Hp) infection in the occurrence of non-cardial gastric adenocarcinoma is suggestive but still debated. This study aimed to evaluate: a) the prevalence of Helicobacter-like organisms in antral bioptic specimens of 291 patients with chronic gastritis with antral atrophy and different subtypes of intestinal metaplasia (IM); b) the presence of a possible different positive tissue staining for the bacteria in the complete and incomplete intestinal metaplasia. Of the 291 patients, 222 cases (76.3%) showed type I IM, 28 cases (9.6%) type II IM and 41 cases (14.1%) type III IM. Helicobacter-like organisms were found in 42.9% of cases and positive tissue staining rate appeared to be inversely related to the extension of IM (58.7% in IM extended in less than 30% of specimens, 30.2% in IM extended between 30% and 60%, 2.7% in IM exceeding 60% of the biopsed area). The inverse correlation between lower positive tissue staining for Helicobacter-like organisms and greater extension of IM was statistically significant (p < 0.001). Incomplete metaplasia appeared to be unrelated to age and associated with a lower positive tissue staining for Helicobacter-like organisms; among patients with type I metaplasia, 118/222 showed Hp-positive bioptic specimens, vs 7/69 of types II and III (p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
幽门螺杆菌（Hp）感染在非贲门部胃腺癌发生中所起的作用虽有迹象表明但仍存在争议。本研究旨在评估：a）291例伴有胃窦萎缩及不同亚型肠化生（IM）的慢性胃炎患者胃窦活检标本中类幽门螺杆菌的患病率；b）完全性和不完全性肠化生中细菌的组织染色阳性情况是否存在差异。291例患者中，222例（76.3%）表现为I型IM，28例（9.6%）为II型IM，41例（14.1%）为III型IM。42.9%的病例发现有类幽门螺杆菌，组织染色阳性率似乎与IM的范围呈负相关（标本中IM范围小于30%时为58.7%，30%至60%时为30.2%，活检面积超过60%时为2.7%）。类幽门螺杆菌组织染色阳性率降低与IM范围扩大之间的负相关具有统计学意义（p < 0.001）。不完全化生似乎与年龄无关，且与类幽门螺杆菌组织染色阳性率较低有关；在I型化生患者中，222例中有118例活检标本Hp阳性，而II型和III型69例中仅有7例（p < 0.001）。（摘要截断于250字）
