Sirigu F, Capeccioni S, Dessì A, Masia A M
Istituto di Medicina Interna, Università degli Studi di Cagliari.
Riv Eur Sci Med Farmacol. 1993 May-Aug;15(3-4):135-8.
To investigate the possible relation between Helicobacter pylori (HP) colonization and incidence of intestinal metaplasia (IM), antral biopsy specimens from a total of 263 subjects (167 had chronic gastritis, 12 gastric cancer, and 84 no histological changes) were examined. IM was observed in 27.7% of the HP positive specimens and in 18.3% of the HP negative biopsies (p = NS). Histochemical characterization of mucins showed that the percentage of HP colonization was not significantly different within various subtypes of IM. We do not find in this study any evidence to support the existence of a pathogenetic role of HP on the morphogenesis of IM in antral mucosa.
为研究幽门螺杆菌（HP）定植与肠化生（IM）发生率之间的可能关系，我们检查了总共263名受试者的胃窦活检标本（167例患有慢性胃炎，12例患有胃癌，84例无组织学改变）。在HP阳性标本中，27.7%观察到肠化生，而在HP阴性活检标本中，这一比例为18.3%（p=无显著性差异）。粘蛋白组织化学特征显示，在不同亚型的肠化生中，HP定植百分比无显著差异。在本研究中，我们未发现任何证据支持HP在胃窦黏膜肠化生形态发生中具有致病作用。
