Arimura H, Nakagawa M, Maruyama Y, Arimura K, Osame M
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University.
Intern Med. 1995 Oct;34(10):995-9. doi: 10.2169/internalmedicine.34.995.
We report a 29-year-old male hemophiliac with human immunodeficiency virus (HIV)-1-associated dementia complex, who died 2.5 months after the onset of dementia. The patient's cognitive abnormalities including forgetfulness, loss of concentration and slowing of thought appeared about 7 years after HIV infection. His neurological symptoms were characterized as progressive dementia, episodic consciousness loss, transverse myelopathy and peripheral neuropathy. He had generalized slow waves in electroencephalogram (EEG), progressive cerebral atrophy and a diffuse high intensity lesion in the white matter as shown by T2-weighted brain magnetic resonance imaging (MRI). We emphasize the significance of neurological complications, especially acute progressive dementia, in Japanese patients with acquired immunodeficiency syndrome (AIDS).
我们报告了一名29岁的男性血友病患者，其患有与人类免疫缺陷病毒1型（HIV-1）相关的痴呆综合征，在痴呆发作2.5个月后死亡。该患者的认知异常，包括健忘、注意力不集中和思维迟缓，在HIV感染约7年后出现。他的神经症状表现为进行性痴呆、发作性意识丧失、横贯性脊髓病和周围神经病变。脑电图（EEG）显示有广泛性慢波，脑磁共振成像（MRI）的T2加权像显示有进行性脑萎缩和白质弥漫性高强度病变。我们强调在日本获得性免疫缺陷综合征（AIDS）患者中神经并发症尤其是急性进行性痴呆的重要性。
