Teterina V I
Biull Eksp Biol Med. 1977 Feb;83(2):228-30.
A study was made of the damaging effect of fractionating X-irradiation (12 rad a day, up to the sum total doses of 250, 500, 750, 1000 and 1500 rad) on the hemopoiesis in guinea pigs. A phasic character of the changes in the erythro- and myelopoiesis during the damage was revealed. The first phase was attented by the activation of the proliferation processes expressed in the increase of mitotic index, reduced duration of the mitotic cycle of the cells belonging to the erythroid and the myeloid series and their accelerated differentiation, this stipulating for a sufficient entrance of the cells into the blood flow and maintaining the erythrocyte and leukocyte content in the peripheral blood approaching the normal level. A reduction of the proliferative processes in the bone marrow was observed during the second phase; these were also a reduction of the mitotic index, prolongation of the mitotic cycle and of the rate cell diferentiation of the erythroid and myeloid series, this being accompanied by anemia and leukopenia in the peripheral blood.
研究了分次X线照射（每天12拉德，总剂量达250、500、750、1000和1500拉德）对豚鼠造血功能的损伤作用。揭示了损伤过程中红细胞生成和粒细胞生成变化的阶段性特征。第一阶段的特点是增殖过程激活，表现为有丝分裂指数增加、红系和髓系细胞有丝分裂周期持续时间缩短以及分化加速，这使得足够数量的细胞进入血流，并使外周血中的红细胞和白细胞含量维持在接近正常水平。第二阶段观察到骨髓增殖过程减少；表现为有丝分裂指数降低、有丝分裂周期延长以及红系和髓系细胞分化速率减慢，同时外周血出现贫血和白细胞减少。
