Lee E J, Wong J Y, Yeoh P N, Gong N H
Department of Pharmacology, National University of Singapore.
Pharmacogenetics. 1995 Oct;5(5):332-4. doi: 10.1097/00008571-199510000-00010.
Glutathione S-transferase-theta (GSTT1) is subject to a genetic polymorphism where approximately 50% of a Caucasian population are homozygous for the null allele. Because of the possible association of the polymorphism with increased cancer risk in individuals, we genotyped by polymerase chain reaction 187 normal Chinese, 167 normal Malays and 152 normal Indians from Singapore and Malaysia. The proportion of Chinese, Malays and Indians with the null genotype were 58%, 38% and 16% respectively and mirrored previously reported frequencies of the GSTM1 null genotype in these populations. The frequency of the combined GSTM1 and GSTT1 null genotypes among Chinese, Malays and Indians were 37%, 22% and 5% respectively. The similarity with predicted frequencies indicated no interaction between the two genetic polymorphisms.
谷胱甘肽S-转移酶-θ（GSTT1）存在基因多态性，在白种人群中约50%的个体为无效等位基因纯合子。鉴于该多态性可能与个体患癌风险增加有关，我们采用聚合酶链反应对来自新加坡和马来西亚的187名中国正常人、167名马来西亚正常人和152名印度正常人进行基因分型。中国、马来西亚和印度人群中无效基因型的比例分别为58%、38%和16%，与先前报道的这些人群中GSTM1无效基因型的频率相符。中国、马来西亚和印度人群中GSTM1和GSTT1联合无效基因型的频率分别为37%、22%和5%。与预测频率的相似性表明这两种基因多态性之间不存在相互作用。
