新加坡不同种族群体中的谷胱甘肽 - S - 转移酶（GST）多态性，并报告基因座1和2处的其他等位基因。

Glutathione-S-transferase (GST) polymorphism among ethnic groups in Singapore with report of additional alleles at loci 1 and 2.

作者信息

Bhattacharyya S P, Saha N, Wee K P

机构信息

Department of Physiology, Faculty of Medicine, National University of Singapore.

出版信息

Gene Geogr. 1989 Apr;3(1):21-6.

PMID:2487053

Abstract

Glutathione S-transferases (GST; E.C.2.5.1.18) were phenotyped by starch gel electrophoresis in post-mortem liver samples from 683 unrelated subjects of both sexes. 305 were Chinese, 185 Indians, 147 Malays and 46 from other racial groups of South-East Asia. GST1 and GST2 were found to be polymorphic in these populations. Additional alleles (GST13 and GST2O) were observed at low frequency in all the ethnic groups. The frequency of GST11 was lower and that of GST12 was higher in Indians and Malays as compared to Chinese. GST10 and GST13 frequencies were similar in all these ethnic groups. The gene frequencies of the alleles of the GST2 locus varied significantly in the population studied. GST20 frequency was significantly higher in Indians than in Chinese and Malays, while the lowest frequency of GST21 was found in the Indians. GST2*2 frequency was higher in the Malays than in Chinese and Indians. GST1 and GST2 phenotype distributions were in agreement with Hardy-Weinberg equilibrium in all the ethnic groups studied. Sex made no significant difference in the phenotype distribution.

摘要

通过淀粉凝胶电泳对683名来自不同种族的男女尸检肝脏样本中的谷胱甘肽S-转移酶（GST；E.C.2.5.1.18）进行表型分析。其中305人为中国人，185人为印度人，147人为马来人，46人来自东南亚其他种族群体。发现GST1和GST2在这些人群中具有多态性。在所有种族群体中均观察到低频的额外等位基因（GST13和GST2O）。与中国人相比，印度人和马来人中GST11的频率较低，GST12的频率较高。GST10和GST13的频率在所有这些种族群体中相似。在研究人群中，GST2基因座等位基因的基因频率差异显著。GST20在印度人中的频率显著高于中国人和马来人，而GST21在印度人中的频率最低。GST2*2在马来人中的频率高于中国人和印度人。在所有研究的种族群体中，GST1和GST2表型分布均符合哈迪-温伯格平衡。性别在表型分布上无显著差异。