Lopez O L, Brenner R P, Becker J T, Jungreis C A, Rezek D, DeKosky S T
Department of Neurology, University of Pittsburgh School of Medicine, Pa., USA.
Dementia. 1995 Nov-Dec;6(6):343-7. doi: 10.1159/000106968.
We evaluated the relationship between periventricular white matter lesions (PWMLs) and EEG abnormalities in probable Alzheimer's disease (AD). We visually analyzed the EEG of 27 probable AD patients with mild to moderate degree of cognitive impairment participating in a longitudinal study of dementia. Patients had both CT and MRI scans performed at baseline examination, which also included an EEG. PWMLs were rated in CT and MRI films using a semiquantitative method. The EEGs were classified according to the Mayo Clinic Classification System. Abnormal EEGs correlated with PWMLs rating scores were detected on CT, but not on MRI. These data suggest that the presence of PWMLs contribute to the abnormal EEGs observed in AD patients, and that white matter abnormalities in CT correlate better with both the clinical findings and EEG than does the more sensitive but less specific MRI.
我们评估了可能患有阿尔茨海默病（AD）的患者脑室周围白质病变（PWMLs）与脑电图异常之间的关系。我们对27名患有轻度至中度认知障碍的可能患有AD的患者的脑电图进行了视觉分析，这些患者参与了一项痴呆症纵向研究。患者在基线检查时进行了CT和MRI扫描，其中也包括脑电图检查。使用半定量方法对CT和MRI片子中的PWMLs进行评分。脑电图根据梅奥诊所分类系统进行分类。在CT上检测到与PWMLs评分相关的异常脑电图，但在MRI上未检测到。这些数据表明，PWMLs的存在导致了AD患者中观察到的脑电图异常，并且CT中的白质异常与临床发现和脑电图的相关性比更敏感但特异性较低的MRI更好。
