Hocking L B, Breitner J C
Department of Psychiatry, Duke University Medical Center, Durham, N.C., USA.
Dementia. 1995 Nov-Dec;6(6):355-6. doi: 10.1159/000106970.
The cumulative risk of Alzheimer-like dementia (AD) was investigated in first-degree relatives (n = 176) of 35 probands with autopsy-confirmed clinical diagnoses of Alzheimer's disease. Seventeen of the 176 first-degree relatives showed evidence of AD. Cumulative morbid risk for the first-degree relatives was estimated to be 28.8%. This result is broadly consistent with previously reported studies, and affirms the presence of substantial disease risk in close relatives of those with Alzheimer's disease.
对35名经尸检确诊为阿尔茨海默病临床诊断的先证者的一级亲属（n = 176）进行了阿尔茨海默样痴呆（AD）累积风险的调查。176名一级亲属中有17名显示出AD的证据。一级亲属的累积发病风险估计为28.8%。这一结果与先前报道的研究大致一致，并证实了阿尔茨海默病患者的近亲中存在重大疾病风险。
