经尸检确诊的阿尔茨海默病病例亲属中患阿尔茨海默样痴呆的累积风险。

Cumulative risk of Alzheimer-like dementia in relatives of autopsy-confirmed cases of Alzheimer's disease.

作者信息

Hocking L B, Breitner J C

机构信息

Department of Psychiatry, Duke University Medical Center, Durham, N.C., USA.

出版信息

Dementia. 1995 Nov-Dec;6(6):355-6. doi: 10.1159/000106970.

DOI:10.1159/000106970

PMID:8563790

Abstract

The cumulative risk of Alzheimer-like dementia (AD) was investigated in first-degree relatives (n = 176) of 35 probands with autopsy-confirmed clinical diagnoses of Alzheimer's disease. Seventeen of the 176 first-degree relatives showed evidence of AD. Cumulative morbid risk for the first-degree relatives was estimated to be 28.8%. This result is broadly consistent with previously reported studies, and affirms the presence of substantial disease risk in close relatives of those with Alzheimer's disease.

摘要

对35名经尸检确诊为阿尔茨海默病临床诊断的先证者的一级亲属（n = 176）进行了阿尔茨海默样痴呆（AD）累积风险的调查。176名一级亲属中有17名显示出AD的证据。一级亲属的累积发病风险估计为28.8%。这一结果与先前报道的研究大致一致，并证实了阿尔茨海默病患者的近亲中存在重大疾病风险。