膀胱癌与职业：意大利北部的一项病例对照研究。
Bladder cancer and occupation: a case-control study in northern Italy.
作者信息
Porru S, Aulenti V, Donato F, Boffetta P, Fazioli R, Cosciani Cunico S, Alessio L
机构信息
Institute of Occupational Health, University of Brescia, Italy.
出版信息
Occup Environ Med. 1996 Jan;53(1):6-10. doi: 10.1136/oem.53.1.6.
OBJECTIVES
A hospital based case-control study was conducted between 1992 and 1993 in the province of Brescia, a highly industrialised area in northern Italy, to evaluate occupational risk factors of bladder cancer.
METHODS
The study evaluated 355 histologically confirmed cases of bladder cancer (275 men, 80 women) and 579 controls affected by urological non-neoplastic diseases (397 men, 182 women). Lifetime occupational history, smoking and drinking habits, and sociodemographic characteristics were recorded by means of a structured questionnaire. Odds ratios (ORs) were computed with adjustment for age, smoking, alcohol and coffee consumption, education, and place of residence.
RESULTS
A significant (P < 0.05) increase of risk of bladder cancer were found in men for labourers in the construction industry (OR 2.1, 95% confidence interval (95% CI) 1.1-3.9) and for recreational and cultural services (OR 5.0, 95% CI 1.3-18.9). Increased risks, although not significant, were found for various other occupations and industries such as machinery mechanics, metal processers and polishers, blacksmiths, gunsmiths, painters; for transport workers, an increased risk with increasing duration of employment was found.
CONCLUSIONS
Occupational exposures seem to contribute to bladder cancer risk in the area under study.
目的
1992年至1993年期间，在意大利北部高度工业化的布雷西亚省进行了一项基于医院的病例对照研究，以评估膀胱癌的职业危险因素。
方法
该研究评估了355例经组织学确诊的膀胱癌病例（275名男性，80名女性）和579名患有泌尿系统非肿瘤性疾病的对照者（397名男性，182名女性）。通过结构化问卷记录终生职业史、吸烟和饮酒习惯以及社会人口学特征。计算比值比（OR），并对年龄、吸烟、饮酒和咖啡消费、教育程度以及居住地点进行调整。
结果
在男性中，发现建筑业劳动者（OR 2.1，95%置信区间（95%CI）1.1 - 3.9）以及娱乐和文化服务行业从业者（OR 5.0，95%CI 1.3 - 18.9）患膀胱癌的风险显著增加（P < 0.05）。在其他各种职业和行业中也发现了风险增加，尽管不显著，如机械技工、金属加工和抛光工、铁匠、枪械工、油漆工；对于运输工人，发现随着就业时间延长风险增加。
结论
在所研究的地区，职业暴露似乎会增加患膀胱癌的风险。
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