抗雌激素导致的晶状体混浊：他莫昔芬与 ICI 182,780 的比较
Lens opacification by antioestrogens: tamoxifen vs ICI 182,780.
作者信息
Zhang J J, Jacob T J, Hardy S P, Higgins C F, Valverde M A
机构信息
Department of Physiology, University of Wales, Cardiff.
出版信息
Br J Pharmacol. 1995 Aug;115(8):1347-8. doi: 10.1111/j.1476-5381.1995.tb16622.x.
Abstract
The antioestrogen, tamoxifen, blocks volume-regulated chloride channels and reduces transparency in bovine lenses maintained in vitro. In contrast to tamoxifen, the steroidal antioestrogen, ICI 182780, did not block volume-regulated chloride currents in three cultured cell lines and required 10 fold higher concentration to induce significant opacification of bovine lenses maintained in vitro. These data suggest that ocular toxic side effects will be minimized by use of the steroidal (ICI 182780) rather than nonsteroidal antioestrogens (tamoxifen).
摘要
抗雌激素药物他莫昔芬可阻断容积调节性氯通道，并降低体外培养的牛晶状体的透明度。与他莫昔芬不同，甾体类抗雌激素药物ICI 182780在三种培养细胞系中并未阻断容积调节性氯电流，且需要高10倍的浓度才能在体外培养的牛晶状体中诱导出明显的浑浊。这些数据表明，使用甾体类（ICI 182780）而非非甾体类抗雌激素药物（他莫昔芬）可将眼部毒性副作用降至最低。
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2
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J Steroid Biochem Mol Biol. 1993 Dec;47(1-6):107-14. doi: 10.1016/0960-0760(93)90063-3.
3
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