溶血磷脂酰胆碱对大鼠肠系膜动脉中乙酰胆碱诱导的内皮依赖性超极化和舒张的选择性抑制作用的证据。
Evidence for selective inhibition by lysophosphatidylcholine of acetylcholine-induced endothelium-dependent hyperpolarization and relaxation in rat mesenteric artery.
作者信息
Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A
机构信息
Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan.
出版信息
Br J Pharmacol. 1995 Sep;116(1):1541-3. doi: 10.1111/j.1476-5381.1995.tb16370.x.
Abstract
The effects of lysophosphatidylcholine (LPC) on acetylcholine-induced hyperpolarization and relaxation were examined in rat mesenteric arteries. LPC (3-10 microM) reversibly inhibited endothelium-dependent hyperpolarization by acetylcholine in a concentration-dependent manner. LPC (10 microM) inhibited only partially endothelium-dependent relaxation by acetylcholine. However, acetylcholine-induced relaxation obtained in the presence of 100 microM NG-nitro-L-arginine was almost completely eliminated by 10 microM LPC. These results indicate that LPC inhibits hyperpolarization and relaxation due to endothelium-derived hyperpolarizing factor more specifically than the relaxation due to endothelium-derived nitric oxide.
摘要
在大鼠肠系膜动脉中研究了溶血磷脂酰胆碱（LPC）对乙酰胆碱诱导的超极化和舒张的影响。LPC（3 - 10微摩尔）以浓度依赖的方式可逆地抑制乙酰胆碱引起的内皮依赖性超极化。LPC（10微摩尔）仅部分抑制乙酰胆碱引起的内皮依赖性舒张。然而，在存在100微摩尔NG-硝基-L-精氨酸的情况下获得的乙酰胆碱诱导的舒张几乎被10微摩尔LPC完全消除。这些结果表明，LPC对内皮源性超极化因子引起的超极化和舒张的抑制作用比内皮源性一氧化氮引起的舒张更具特异性。
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本文引用的文献
1
Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.磷脂酶A2活性在内皮细胞诱导的低密度脂蛋白修饰中的重要作用。
Proc Natl Acad Sci U S A. 1985 May;82(9):3000-4. doi: 10.1073/pnas.82.9.3000.
2
Differential role of extra- and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells.细胞外钙和细胞内钙在培养的内皮细胞释放内皮舒张因子和前列环素中的不同作用。
Br J Pharmacol. 1988 Sep;95(1):189-96. doi: 10.1111/j.1476-5381.1988.tb16564.x.
3
Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.兔和人动脉粥样硬化病变中存在氧化修饰低密度脂蛋白的证据。
J Clin Invest. 1989 Oct;84(4):1086-95. doi: 10.1172/JCI114271.
4
Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.动脉粥样硬化的人冠状动脉和兔主动脉中，毒蕈碱介导的内皮依赖性舒张及环磷酸鸟苷生成受损。
J Clin Invest. 1987 Jan;79(1):170-4. doi: 10.1172/JCI112779.
5
Lysophosphatidylcholine: essential role in the inhibition of endothelium-dependent vasorelaxation by oxidized low density lipoprotein.溶血磷脂酰胆碱：在氧化低密度脂蛋白抑制内皮依赖性血管舒张中起关键作用。
Biochem Biophys Res Commun. 1990 Apr 16;168(1):301-8. doi: 10.1016/0006-291x(90)91708-z.
6
Calcium dependency of the endothelium-dependent hyperpolarization in smooth muscle cells of the rabbit carotid artery.兔颈动脉平滑肌细胞中内皮依赖性超极化的钙依赖性
J Physiol. 1990 Feb;421:521-34. doi: 10.1113/jphysiol.1990.sp017959.
7
Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins.
Nature. 1990 Mar 8;344(6262):160-2. doi: 10.1038/344160a0.
8
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Circ Res. 1992 Apr;70(4):660-9. doi: 10.1161/01.res.70.4.660.
9
Endothelium-derived hyperpolarizing factor (EDHF).
Jpn Circ J. 1992 Feb;56(2):170-4. doi: 10.1253/jcj.56.170.
10
Lysophosphatidylcholine inhibits bradykinin-induced phosphoinositide hydrolysis and calcium transients in cultured bovine aortic endothelial cells.
Circ Res. 1992 Dec;71(6):1410-21. doi: 10.1161/01.res.71.6.1410.
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