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新型抗结核疫苗的前景

Prospects for new vaccines against tuberculosis.

作者信息

Orme I M

机构信息

Dept of Microbiology, Colorado State University, Fort Collins 80523, USA.

出版信息

Trends Microbiol. 1995 Oct;3(10):401-4. doi: 10.1016/s0966-842x(00)88987-8.

DOI:10.1016/s0966-842x(00)88987-8
PMID:8564360
Abstract

The spectacular failure of the existing bacille Calmette-Guérin (BCG) vaccine in recent tuberculosis-control trials has prompted a search for potential replacements. Imaginative approaches currently under development include the modulation of BCG by the production of auxotrophic mutants or cytokine-secreting recombinants, and the development of subunit vaccines based on the major proteins of Mycobacterium tuberculosis.

摘要

现有卡介苗（BCG）疫苗在近期结核病控制试验中的惊人失败促使人们寻找潜在的替代疫苗。目前正在开发的创新方法包括通过生产营养缺陷型突变体或分泌细胞因子的重组体来改造卡介苗，以及开发基于结核分枝杆菌主要蛋白的亚单位疫苗。

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Prospects for new vaccines against tuberculosis.新型抗结核疫苗的前景
Trends Microbiol. 1995 Oct;3(10):401-4. doi: 10.1016/s0966-842x(00)88987-8.
2
Recombinant bacille Calmette-Guerin coexpressing Ag85b, CFP10, and interleukin-12 elicits effective protection against Mycobacterium tuberculosis.重组卡介苗共表达 Ag85b、CFP10 和白细胞介素-12 可有效预防结核分枝杆菌感染。
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Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against tuberculosis.通过DNA免疫进行的预激发增强了卡介苗对结核病的保护效力。
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Construction and evaluation of a multistage Mycobacterium tuberculosis subunit vaccine candidate Mtb10.4-HspX.构建并评价结核分枝杆菌多阶段亚单位疫苗候选物 Mtb10.4-HspX。
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Beyond BCG: the potential for a more effective TB vaccine.超越卡介苗：研发更有效结核病疫苗的潜力
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引用本文的文献

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Front Immunol. 2017 May 15;8:556. doi: 10.3389/fimmu.2017.00556. eCollection 2017.
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Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis.用减毒结核分枝杆菌进行黏膜疫苗接种可诱导强烈的中枢记忆反应并预防结核病。
Nat Commun. 2015 Oct 13;6:8533. doi: 10.1038/ncomms9533.
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Humoral and lung immune responses to Mycobacterium tuberculosis infection in a primate model of protection.
在灵长类动物保护模型中对结核分枝杆菌感染的体液免疫和肺部免疫反应。
Trials Vaccinol. 2014 Mar 13;3:47-51. doi: 10.1016/j.trivac.2014.02.001.
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Granuloma correlates of protection against tuberculosis and mechanisms of immune modulation by Mycobacterium tuberculosis.结核分枝杆菌感染肉芽肿相关性保护作用及免疫调节机制
J Infect Dis. 2013 Apr;207(7):1115-27. doi: 10.1093/infdis/jis778. Epub 2012 Dec 18.
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